Health Biotechnology and BiopharmaHealth Biotechnology and Biopharma (HBB)2538-44141320171201Pharmacy informatics: A reform at drug consumption management in healthcare1413385310.22034/HBB.2017.23ENJournal Article20210719In recent decades, since the pharmacy has a key role in patient care, advancement in information technology has created many opportunities for pharmacists and pharmacies to leverage informatics to support their practice and improve care.https://www.healthbiotechpharm.org/article_133853_e184ba4c6cdf08d01315fd99867a091c.pdfHealth Biotechnology and BiopharmaHealth Biotechnology and Biopharma (HBB)2538-44141320210719The role of G9a gene in various cancers51113385410.22034/HBB.2017.14ENJournal Article20210719G9a is an epigenetic regulator that methylate the lysine 9 of histone 3 and has a role in gene silencing. G9a generally causes repression of gene expression and participates in diverse cellular functions such as DNA repairing, proliferation and differentiation. This gene is overexpressed in some types of cancers include lung, colorectal, endometrial, head and neck cancers. The role of this gene in the basic processes can be used as a therapeutic goal. The purpose of this study was to evaluate the expression of G9a gene in various cancers and cancer related activities in this gene.https://www.healthbiotechpharm.org/article_133854_46be09086c8e0fef55a816b373a29a7e.pdfHealth Biotechnology and BiopharmaHealth Biotechnology and Biopharma (HBB)2538-44141320171201Solid-liquid biphasic distributive bio systems; a novel method for removal of contaminants122413385610.22034/HBB.2017.15ENJournal Article20210719Solid-liquid biphasic biosystems contains two phases; aqueous phase containing the microorganisms and polymeric solid phase. Non aqueous phase has various applications including faster removal of hydrophobic contaminants and release them to the aqueous environment for better decomposition by microorganisms, controlling the concentration of toxic and inhibitor substrates and isolation of the limiting reagents of the reaction from the environment. The major advantages of polymer use are nontoxicity for microorganisms, improbability to be used as a carbon source and very low price compared to the organic liquid phase. Using cheap, non-volatile, inflammable and easily felxible polymers as the second phase leads to design a biological process with high efficiency and low cost which is called the green process without the solvent.<br />In thisreview, the mechanism of action of this type of biphasic systems and the methods to choose the solid phase was introduced followed by the various applications of these systems.https://www.healthbiotechpharm.org/article_133856_0c38d50466ddea48e20b4203280e570f.pdfHealth Biotechnology and BiopharmaHealth Biotechnology and Biopharma (HBB)2538-44141320171201Evaluating antimicrobial effects of different orange blossom extract (Citrus aurantium L) on microbial species in vitro253613385710.22034/HBB.2017.16ENJournal Article20210719Citrus aurantium L is rich of flavonoids, many flavones, volatile compounds and monoterpenes hydrocarbons. Orange blossom extract has antioxidant and antimicrobial features. In Iranian traditional medicine, orange blossom is known as a comforting and sleep booster plant. According to disrupt and side effects of chemicals and its high costs, the use of herbs in the prevention and treatment of bacterial factors is very important, also different extracts and biological and pharmaceutical properties on the bacteria species were studied by sink and micro dilution methods. Extraction was done with aqueous methanol and acetone solvents using percolation method and then were dried. Different concentrations were prepared from concentrated extracts for disc diffusion and MIC. The results showed that the antimicrobial properties of acetone extract are better than methanol and water extracts by micro dilution method on Klebseilla and the related MIC is 100 mg/ml. The average diameter of inhibition zone was 11.33 mm. Methanol extracts had better activity on E.coli. The related MBC and average diameter were 150 mg/ml and 12 mm, respectively. Orange blossom showed antibacterial effects for higher concentration of methanol and acetone.https://www.healthbiotechpharm.org/article_133857_bc5b064c55bbaadc988987da2c70a2f6.pdfHealth Biotechnology and BiopharmaHealth Biotechnology and Biopharma (HBB)2538-4414132017120131P-NMR study for determination of coumarin antifungal mechanism of action375113385910.22034/HBB.2017.17ENJournal Article20210719Coumarin derivatives as antifungal bioactive agents have been considered for many years. However, their mechanism of action is not very clear. In the current paper, antifungal activity of natural and synthetic coumarins are studied against Cryptococcus neoformans and Saccharomyces cerevisiae. Mechanism of pH-dependent activity of coumarin compounds was investigated using 31P-NMR spectra and even intracellular estimate of the pH values. The results showed that coumarin derivatives have inhibitory effects without any noticeable side effects through a selective ATPase inhibitory mechanism.https://www.healthbiotechpharm.org/article_133859_17be46bd101cf7f3872ad2f5da5c9757.pdfHealth Biotechnology and BiopharmaHealth Biotechnology and Biopharma (HBB)2538-44141320171201Platelet rich plasma effect on tissue healing after mandibular third molar surgery526413386010.22034/HBB.2017.18ENJournal Article20210719The purpose of this investigation was to assess the effect of platelet rich plasma (PRP) on soft tissue healing after mandibular third molar surgery. In this semi-blinded clinical trial study, 30 patients requiring surgical extraction of soft tissue impacted mandibular third molar and who indicated a willingness to return for recall visits were recruited. Patients were divided into test and control groups. In the test group, PRP was placed in the extracted socket, whereas the control group had no PRP. The mean postoperative pain score (Visual Analog Scale) and the amount of wound dehiscence were lower for the test group and it was statistically significant. Although the mean bleeding time was lower in the test group, this difference was not significant. The dry socket incidence and the mean intrinsical mouth opening were not significant between both groups. The PRP in the test group reduced pain and better soft tissue healing compared with in the control group. This study showed that topical application of PRP had a beneficial effect in enhancing socket healing after third molar surgery.https://www.healthbiotechpharm.org/article_133860_b82d6e3c23338afdadff1a5fcbf672f1.pdfHealth Biotechnology and BiopharmaHealth Biotechnology and Biopharma (HBB)2538-44141320171201Phytoconstituents and biological activities of Artemisia kopetdaghensis657613386110.22034/HBB.2017.19ENJournal Article20210719Phytochemical investigation of the aerial parts of Artemisia kopetdaghensis led to isolation and characterization of 5 compounds including 9-Oxo-tournefortiolide (1), 2,6,10-Trimethyl-2,5-epidioxy-7,10-epoxydodeca-3,11-dien-5-acetoxy (2), 6-Demethoxy-5,7-dihydroxy-4'-O-methylcapillarisin (3), Eupatilin (4) and 5, 7, 5'-trihydroxy-6, 2´, 4´-trimethoxyflavone (5). The chemical structures of these compounds were identified by spectroscopic analysis. The antioxidant activities of the pure compounds were evaluated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assays and also the antimicrobial capacity were tested against gram positive and gram negative bacteria and fungi using minimum inhibitory concentration (MIC) method.https://www.healthbiotechpharm.org/article_133861_c856a355a55cfe13e4e1eb21b4d1e66a.pdfHealth Biotechnology and BiopharmaHealth Biotechnology and Biopharma (HBB)2538-44141320171201PEG derivatives, a new platform technology for pharmaceutical research in drug delivery778013386210.22034/HBB.2017.20ENJournal Article20210719Methoxy polyethylene glycol (mPEG) with high molecular weight which has been used as a coating agent in drug delivery systems leads to more therapeutic efficacy. This supports the hypothesis that coating the drugs with higher molecular weight of PEG derivatives. The coating agent, methoxy polyethylene glycol propionaldehyde 20KDa (mPEG-ALD 20KDa), is a new platform technology for pharmaceutical research in drug delivery.https://www.healthbiotechpharm.org/article_133862_704f65dd60267d06d6478dd33b9103e2.pdf