Health Biotechnology and BiopharmaHealth Biotechnology and Biopharma (HBB)2538-44144420210301Telomere shortening occurs in patients with ectodermal dysplasia1513293810.22034/HBB.2021.01ENJournal Article20210703Ectodermal Dysplasia (ED) is a rare congenital disorder that is characterized by sparse hair, lack or absence of sweat glands, and rod-shaped teeth, which are diagnosed by two or three of these features. There are approximately 200 subtypes of ED have been identified. One of the rare and severe subtypes of ED is Dyskeratosis Congenita (DC). A mutation in the telomere-maintain genes causes this disorder. Since this rare disorder is a subset of ED disease, this study aimed to examine telomeres in these patients and expect to see telomere shortening in ED patients.https://www.healthbiotechpharm.org/article_132938_93305670ac3f9179427a7bc8e87f1e93.pdfHealth Biotechnology and BiopharmaHealth Biotechnology and Biopharma (HBB)2538-44144420210301Traditional herbal medicine in the treatment of patients infected with new Coronavirus61513294010.22034/HBB.2021.02ENJournal Article20210703The purposes of this review was in the direction of epidemiology, causative agents, symptoms, vaccine research probabilities and COVID-19 infection novel Corona viruses that was investigated in China. The COVID-19 has surrounded viruses along with a practical sensation one stranded RNA genome and a nucleocapsid of helical uniformity. The COVID-19 is an enormous family of viruses that are prevalent in a public and large number of species of animals including hens, camels, bats, cat, and cattle. Human corona viruses can cause gentle disorder identical to a common cough, cold, while others reason more acute disease MERS (Middle East Respiratory Syndrome) and SARS (Severe Acute Respiratory Syndrome). Thus spreading the COVID-19 should be closely investigated to recognize the growth of particularly virulent strains in society at an early stage and to simplify the evolution of enough preventive and therapeutic measurements.https://www.healthbiotechpharm.org/article_132940_721c2b482fa66c91adc91d339c762313.pdfHealth Biotechnology and BiopharmaHealth Biotechnology and Biopharma (HBB)2538-44144420210301Comparison of the transmission and detection potential of COVID-19 virus and other viruses in tear fluids163113294410.22034/HBB.2021.03ENJournal Article20210703The COVID-19 virus is a subgroup of zoonotic viruses. The most terrible problem started when the number of infected patients with acute respiratory syndrome quickly spread around the world, which made it as a global pandemic. This novel virus could transmitted from person to person via infected droplet entering the respiratory system whether nasal or oral cavity. Close contact less than 6 feet, with infected individuals particularly in crowded environments has characterized the rapid spread of the infection. Clinical signs of the COVID-19 infection have mentioned the presence of some ocular findings such as conjunctival congestion, conjunctivitis and even corneal injury associated with the classical COVID-19 infection. In this review, we showed that different viruses could be and transmitted by tear fluid which encourage us to search regarding to this potential in COVID-19 virus.https://www.healthbiotechpharm.org/article_132944_f792db42cde0dd83535661e32de36655.pdfHealth Biotechnology and BiopharmaHealth Biotechnology and Biopharma (HBB)2538-44144420210301Health counseling, genetic background, and safety against tetanus in women referring to premarital center324213294610.22034/HBB.2021.04ENJournal Article20210703Since immunization of women of childbearing age through vaccination and antibody transfer to the fetus, reduces the likelihood of the infant getting the tetanus. This study was conducted for examining the safety status of tetanus in women referred to premarital center. This study was performed on 181 women referring to a clinic in Yazd, Iran. Blood samples were measured by ELISA method and data were analyzed by SPSS software. The immunity status of individuals against tetanus was significantly correlated with vaccination status and occupation but with number of family children (genetic status) and several parameters was no a significant correlation. By measuring the antibody, it is possible to identify groups at risk for immunization against tetanus and modify the vaccination.https://www.healthbiotechpharm.org/article_132946_8b859fcb2839503fce4a0f6a3b765977.pdfHealth Biotechnology and BiopharmaHealth Biotechnology and Biopharma (HBB)2538-44144420210301The assessment of lifestyle change due to COVID-19 pandemic in northern Iraq435013294710.22034/HBB.2021.05ENJournal Article20210703The aim of this study was to assess the effect of Coronavirus disease-19 (CoVID-19) on body and daily activity in Kurdistan Region, Iraq. This study was conducted among 320 participants using an online application. The questionnaire included items related to negative impact of CoVID-19 on daily life. The weight gaining included little (46 %) and severe (25 %). Sleep disturbance was less affected (24 % little and 8 % severe). The impact on daily living routines included 38 % little and 50 % severe (p= 0.04). Notably, 47 % (p = 0.001) of participants had severe deacrease in daily output (p=0.041). The quarantine and disturbed lifestyle during COVID-19 caused significant changes in body and daily activity or output in Northern Iraq.https://www.healthbiotechpharm.org/article_132947_9f556b8e197bde4b0231e2232780716b.pdfHealth Biotechnology and BiopharmaHealth Biotechnology and Biopharma (HBB)2538-44144420210301In silico evaluation of surface-exposed proteins of severe acute respiratory syndrome coronavirus 2 to propose a multi-epitope vaccine candidate517213294810.22034/HBB.2021.06ENJournal Article20210703The novel Coronavirus disease 2019 caused a global outbreak therefore a promising vaccine is needed to combat it. In this study, the Spike (S) glycoprotein, Membrane (M) protein, and Envelope (E) protein have been tested as putative vaccine candidates. It was demonstrated that the second protrusion part of M protein contains several immunogenic epitopes. On the other hand, the S2 domain of S protein was found to be highly conserved. Therefore, we proposed a fusion protein as a multiepitope-based subunit vaccine including the second protrusion part of M protein and S2 domain of S protein with a flexible linker. Finally, the 3D structure and physicochemical properties of this fusion protein were evaluated to select a stable structure.https://www.healthbiotechpharm.org/article_132948_5bdf1d60e2e9ae308a4f2376df515e3b.pdf