Volume 7 (2023-2024)
Volume 6 (2022-2023)
Volume 5 (2021-2022)
Volume 4 (2020-2021)
Volume 3 (2019-2020)
Volume 2 (2018-2019)
Volume 1 (2017-2018)
Number of Articles: 181
Thermal stability and pH of antioxidant activity of ethanol extract of Ciplukan herbs (Physalis angulata Linn) along with determination of pKa
Volume 7, Issue 2 , September 2023, , Pages 52-65
Abstract
In this study, thermal stability and pH for the antioxidant activity of the ethanol extract of ciplukan (Physalis angulata Linn) herbs had been studied. Among the antioxidant activity methods, the use of DPPH (2,2-diphenyl-1-picrylhydrazyl) reagent is simple and easy to use. The thermal effect was observed ... Read MorePrevalence and impact of coagulation dysfunction in patients with COVID-19 in Yazd
Volume 6, Issue 1 , June 2022, , Pages 53-61
Abstract
Covid-19 patients have coagulation complications resulting in poor prognosis. Therefore, this study aimed to investigate the prevalence of coagulation disorders in patients with Covid-19 admitted to Shahid Sadoughi Hospital in Yazd. This study was a cross-sectional study that all patients admitted with ... Read MoreCytotoxicity, anti-adhesive and anti-angiogenic effects of Caspian Cobra snake (Naja oxiana) venom on human endothelial cells
Volume 1, Issue 1 , June 2017, , Pages 54-63
Abstract
Snake bite was known as one of the most important public health concerns world wild. Respiratory and cardiac problems and destruction of endothelium system occurs as a result of snake bite. Some proteins and peptides in snake venom have potential for drug discovery studies. According to the important ... Read MoreDNA damage protection by fatty acid rich fractions from Andrographis Paniculata Nees (AP): An in vitro study
Volume 5, Issue 4 , March 2022, , Pages 55-85
Abstract
As antioxidants prevent free radical caused DNA damage, they lower the risk of developing chronic diseases. The present study evaluated the impact of fatty acid-rich fractions of Andrographis Paniculata Nees (AP) on free radical-induced DNA damage. We prepared fatty acid-rich fractions with dried AP ... Read MoreTracking of intraperitoneally and direct intrahepatic administered mesenchymal stem cells expressing miR-146a-5p in mice hepatic tissue
Volume 4, Issue 3 , December 2020, , Pages 56-76
Abstract
Given the functional drawbacks in the efficacy and safety of conventional miRNA delivery approaches, we aimed to assess the fate of mesenchymal stem cells (MSCs) expressing miR-146a-5p into the mice hepatic tissue. MSCs were xeno-transplanted through direct intrahepatic and intraperitoneal routes into ... Read MoreOptimized preparation of lysozyme loaded dextran-chitosan nanoparticles using D-optimal design
Volume 2, Issue 4 , March 2019, , Pages 56-78
Abstract
In this study, optimized conditions were investigated using response surface methodology for the preparation of lysozyme loaded dextran-chitosan nanoparticles. Nanoparticles were prepared using polyelectrolyte complexation method. Relevant factors including polymer ratio, protein concentration, stirring ... Read MoreThe basic of bacterial resistance to antimicrobial drugs
Volume 2, Issue 2 , October 2018, , Pages 56-68
Abstract
Drug-resistant organisms may have acquired resistance to first-line antibiotics, thereby obligating the use of second-line agents and so this problem is a serious and pre-eminent public health concern in the 21st century. Evolutionary pressure caused by misuse and overuse of antibiotics has played a ... Read MoreEffect of aqueous extract of Quercus Infectoria gall on the basic contractility, frequency and strength of isolated virgin rat uterus smooth muscle
Volume 1, Issue 4 , March 2018, , Pages 56-65
Abstract
Myometrial contractions have important role in physiological processes such as sperm and embryo transport, implantation, uterus retraction and reducing post-partum hemorrhage. Quercus infectoria (Aleppo oak) is well-known since ancient times as an astringent agent. In the present study, the cumulative ... Read MoreInduction and evaluation of influenza cell-mediated immune responses by HA2 subunit and bio adjuvant as a gene vaccine candidate
Volume 6, Issue 4 , March 2023, , Pages 56-66
Abstract
The stalk domain of influenza as Hemagglutinin 2 (HA2) is a conserved unit of HA and is a candidate for a vaccine construct. We designed HA2/Mx (Myxovirus Resistance) as bio adjuvant construct for vaccine candidates. After immunization of Razi Balb/c mice in DNA/prime/boost strategy, for determination ... Read MoreSimple and fast identification of atropine and atropine-like molecules in some medicinal plant extracts by molecularly imprinted polymers
Volume 4, Issue 2 , September 2020, , Pages 57-69
Abstract
In this study, the extracts of four plants with alkaloid and one plant without alkaloid were used. Datura innoxia Miller, Withania somnifera (L.) Dunal, Physalis alkekengi, Lactuca serriola L. Plants with alkaloids and Salvia sclarea L. without alkaloids that were collected from Tehran and other plants ... Read MoreAnti-tumor activity of Iranian cobra snake (Naja oxiana) venom on lung cancer cell line
Volume 3, Issue 1 , June 2019, , Pages 57-63
Abstract
Drug discovery from the venom of venomous animals is one of the marvelous and cost effective ways.Snake venom is one of the important sources of drug discovery. There are various active biomolecules in the snake venom. N.oxiana venom fractionated and cytotoxic effect of each fraction was examined by ... Read MoreWhole exome sequencing reveals the first c.7456C>T p.Arg2486X mutation in ATM gene in Iranian population
Volume 6, Issue 3 , December 2022, , Pages 57-72
Abstract
Mutations in Ataxia-Telangiectasia Mutated (ATM) gene are prominently responsible for the condition. ATM gene encodes a serine/threonine protein kinase, a crucial component in DNA repair systems. Whole exome sequencing was performed on a nine year old male subject with clinical features of A-T. Alpha ... Read MoreLessons from comparative genome analysis of Acinetobacter baumannii strains
Volume 5, Issue 1 , June 2021, , Pages 58-72
Abstract
The whole-genome sequencing method allows an analysis of genetic differences between bacterial isolates belonging to the same species. In this study, six strains, including Acinetobacter baumannii ACICU (ST2), A. baumannii ATCC 17978 (ST437), A. baumannii ATCC 19606 (ST57), A. baumannii BJAB0868 (ST2), ... Read MoreInvestigating interaction between IL-17A, IL-17E, TNF-α and rs3783605 and its effect on VCAM-1 promoter activity in the human umbilical vein endothelial cells
Volume 4, Issue 1 , June 2020, , Pages 59-67
Abstract
The present study is created to determine the effect of rs3783605 and its interaction with IL-17A, IL-17E and TNF-α cytokines on the action of VCAM-1 gene promoter in human umbilical vein endothelial cells (HUVEC). Recent research shows that IL-17A and TNF-α cytokines have main effect on ... Read MoreChemotherapy, dialysis and transplantation analysis among immunocompromised patients with focus on tuberculosis, syphilis, hepatitis B, C, HIV and chicken pox
Volume 3, Issue 3 , December 2019, , Pages 59-68
Abstract
Immunodeficiency cases are a common cause of hospital deaths in hospitalized patients. Given the high prevalence of nosocomial deaths due to infection in immunocompromised patients, we aimed to evaluate Tuberculosis (TB), syphilis, hepatitis B and C, HIV and chickenpox in hospitalized immunocompromised ... Read MoreInvestigating the protective effect of the methanolic extract of Salvia multicaulis on renal ischemia-reperfusion injuries in rats
Volume 7, Issue 1 , July 2023, , Pages 60-77
Abstract
In this research the protective effects of the methanolic extract of S. multicaulis was evaluated in renal ischaemia-reperfusion injuries in rats. 42 male rats were divided into 6 groups. In the treatment groups 1-3, before causing ischemia in the kidneys, rats received 50, 100, and 150 mg/kg/day doses ... Read MoreGenetically Modified (GM) foods and the risk to human health and environment
Volume 3, Issue 2 , September 2019, , Pages 61-73
Abstract
The three major Genetically Modified (GM) foods such as soybeans, canola and corn have been introduced to the global market since 1990. In this article, the potential health impacts of genetically modified foods is reviewed. Contrary to the present biotechnological claims, transgenic products have not ... Read MoreAssociation study of leptin and leptin receptor gene polymorphisms with diabetes type 2 and obesity
Volume 1, Issue 2 , September 2017, , Pages 61-69
Abstract
The adiposity hormone, leptin, plays an important role in the control of glucose metabolism by its action in the brain. The effects of leptin are reducing body adiposity, food intake and improving insulin sensitivity in peripheral tissue by indirect mechanism. This study was performed to investigate ... Read MoreThe most common symptoms of COVID-19 patients in Yazd
Volume 5, Issue 3 , December 2021, , Pages 61-71
Abstract
The aim of this study was to investigate the most common symptoms of COVID-19 patients in Yazd. This study was done during 2020-2021. All patients with positive PCR test were entered to this study. Finally, data was analyzed by SPSS software. The most common symptoms of COVID-19 patients were shortness ... Read MoreBest insights on target molecules for drug design of nCOVID-19 based on pharmacological and peptide-based therapeutics
Volume 6, Issue 1 , June 2022, , Pages 62-81
Abstract
Coronavirus is a non-segmented virus related to Coronaviridae family with an envelope and RNA that has a huge positive-sense single-stranded genome. The causative agent of COVID-19, severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2) first appeared in China in 2019. The role of these viruses ... Read MoreIntroducing an innovative algorithm based on the abilities of the human perception system towards profiling similarity search of drugs and drug-like compounds such as fluoxetine
Volume 7, Issue 3 , December 2023, , Pages 62-76
Abstract
The current research had been finalized based on the employing interdisciplinary aspects in addition to utilizing skills of cheminformatics in addition to psychosomatic facts towards introducing the innovative Translator Machine System (TMS-CH) for converting small molecule structures to melodic composition ... Read MoreComparing mental performance and hardiness of rural and urban university students in Ahwaz
Volume 3, Issue 4 , March 2020, , Pages 63-71
Abstract
The aim of the present study was to compare mental performance and hardiness of rural university students with urban university students in Shahid Chamran University of Ahwaz. This study had causal-comparative design. Samples were chosen randomly from 159 students (88 urban students and 71 rural students). ... Read MoreVitamin E reduces blood urea concentrations level after formaldehyde exposure in rat
Volume 2, Issue 3 , December 2018, , Pages 63-67
Abstract
In this study, effect of vitamin E on kidney after exposure to formaldehyde was evaluated. 24 adult male wistar rats divided randomly in three groups: control, formaldehyde (E1), vitamin E and formaldehyde (E2). After two weeks rats were sacrificed, and 5 ml of blood was taken from their heart. Blood ... Read MoreInvestigating the effects of Zataria Multiflora essential oil and silver nanoparticles on the expression of abaI and pil genes in Acinetobacter baumannii biofilm formation
Volume 7, Issue 4 , March 2024, , Pages 63-80
Abstract
The aim of this research was to investigate the effect of Zataria multiflora and silver nanoparticles on the biofilm formation ability of A. baumannii and the expression of genes involved in this process. Thirty isolates of A. baumannii bacteria were collected and studied from the Milad Hospital of Tehran. ... Read MoreSynthesis, characterization and antibacterial activity of Co (Ⅱ), Ni (Ⅱ) , Mn (Ⅱ), Cu(Ⅱ) and Zn(Ⅱ) complexes with 2-amino-7,7-dimethyl-5-oxo-4-chlorobenzen 5,6,7,8-tetra hydro-4H-chromene-3-carbonitrile
Volume 1, Issue 1 , June 2017, , Pages 64-71