Effect of spices and aromatic compounds on inhibit COVID_19 Mpro by docking analysis
Volume 4, Issue 3 , December 2020, , Pages 28-46

https://doi.org/10.22034/HBB.2020.16

Abstract
  Coronavirus 2019 is a disaster in the 21st century and the lack of specific medications for prevention or treatment is a major need. In this regard, we conducted a conventional study to identify the main targets of coronavirus among spices compound. For this bioinformatics study, the ingredients structure ...  Read More

Novel coronavirus disease-19: An overviwe of pathogenesis, health influences and measures
Volume 4, Issue 2 , September 2020, , Pages 28-36

https://doi.org/10.22034/HBB.2020.08

Abstract
  The coronavirus disease-19 (COVID-19) signs mostly include fever and respiratory symptoms (unusual viral pneumonia by SARS-Coronaviruses 2 or SARS-CoV-2). The Receptor-Binding Domain (RBD) of COVID-19 and SARS-CoV are similar, causing cross-reactivity of anti-SARS-CoV antibodies with associated spike ...  Read More

Study of drug resistance pattern of Pseudomonas aeroginosa at Shahid Sadoughi and central laboratories of Yazd in Iran
Volume 2, Issue 1 , July 2018, , Pages 28-37

https://doi.org/10.22034/HBB.2018.12

Abstract
  This research aims to assess drug resistance pattern of Pseudomonas aeroginosa. This study cross-sectional was done on 151 positive culture tests of P. aeroginosa from May 2016 until May 2017 in Shahid Sadoughi and central laboratories of Yazd. In this study the sensitivity was evaluated according to ...  Read More

Identification of chemical composition of essential oil and evaluation of antimicrobial effects of ethanolic extract of Mentha pulegium on Staphylococcus aureus and Escherichia coli
Volume 3, Issue 1 , June 2019, , Pages 29-38

https://doi.org/10.22034/HBB.2019.10

Abstract
  Increasing antibiotic resistance in strains of bacterial pathogens increase the attitude of people to find new compounds as an appropriate alternative to antibiotics. In this study, the antimicrobial effects of methanolic extract of Mentha pulegium against S. aureus and E. coli strains were investigated. ...  Read More

Medicinal sciences
Bibliometric analysis: The future of thalassemia disease by utilizing artificial intelligence technology

Erliyan Redy Susanto; Admi Syarif; Warsito Warsito; Khairun Nisa Berawi; Hidayat Hidayat

Volume 7, Issue 3 , December 2023, , Pages 30-44

https://doi.org/10.22034/HBB.2023.22

Abstract
  The use of artificial intelligence to solve surfaces in thalassemia disease has been the focus of popular research in the last decade. However, there are no scientific reports that provide a systematic overview of this scientific field. We used bibliometric approaches to identify and analyze academic ...  Read More

Health counseling, genetic background, and safety against tetanus in women referring to premarital center
Volume 4, Issue 4 , March 2021, , Pages 32-42

https://doi.org/10.22034/HBB.2021.04

Abstract
  Since immunization of women of childbearing age through vaccination and antibody transfer to the fetus, reduces the likelihood of the infant getting the tetanus. This study was conducted for examining the safety status of tetanus in women referred to premarital center. This study was performed on 181 ...  Read More

Expression profiling of matrix metalloproteinase in adipose-derived stem cells under simulated microgravity condition
Volume 2, Issue 4 , March 2019, , Pages 32-39

https://doi.org/10.22034/HBB.2019.04

Abstract
  The extracellular matrix (ECM) provides the cellular environment required during development and morphogenesis. The mechanical forces could influence the expression of ECM components. Matrix metalloproteinase (MMP) is a family of proteolytic enzymes participated in ECM remodeling and degradation. We ...  Read More

Biochemical evaluation of antioxidant activity, phenol and flavonoid contents of Dracocephalum Kotschyi Boiss extracts obtained with different solvents
Volume 1, Issue 4 , March 2018, , Pages 32-44

https://doi.org/10.22034/HBB.2018.03

Abstract
  Dracocephalum Kotschyi Boiss, is one of Dracocephalum species which has been used in traditional Iranian medicine with pharmacological and biological activities. The antioxidant properties and total flavonoid and phenolic contents of three different extracts of Dracocephalum Kotschyi Boiss were investigated. ...  Read More

Biological sciences
The effect of Ajuga reptans extract on in vitro maturation of rat oocytes

Tina mandegarfard; Zahra Arabi; Mahsa Nejati; Nika Mashhadizadeh; Mina Nikandish; Mehdi Ahmadifar

Volume 6, Issue 1 , June 2022, , Pages 33-52

https://doi.org/10.22034/HBB.2022.10

Abstract
  Resumption of nuclear maturation and cytoplasmic changes occur during in vitro maturation. In vitro maturation of the egg provides a stage called Metaphase II (MII) that is required for in vitro fertilization. This study aimed to investigate the effect of replacing Follicle-Stimulating Hormone (FSH) ...  Read More

Formulation development of Ezetimibe by using Soluplus and Co- Processed Acacia: tragacanth with Design Expert

TarakaRamarao Ch; Ravali Jami

Volume 6, Issue 3 , December 2022, , Pages 33-56

https://doi.org/10.22034/HBB.2022.22

Abstract
  Ezetimibe is an antihyperlipidemic drug that lowers cholesterol levels. The purpose of this study was to compare different amounts of solid dispersions and formulations using various carriers in order to improve the dissolution. The Design Expert software was used to perform Analysis of Variance (ANOVA), ...  Read More

Impact of mass media on the population as a precautionary prevention from COVID-19 in Iraq
Volume 5, Issue 2 , September 2021, , Pages 34-45

https://doi.org/10.22034/HBB.2021.17

Abstract
  The aim of this study was to identify the impact of both traditional mass media and social digital media on the population to prevent the Corona virus disease-19 (COVID-19). Three hundred twenty participants were included. A questionnaire was prepared consisting of socio-demographic characteristics and ...  Read More

The role of drinking hydrogen-rich water produced by alkaline stick on resistance exercise in athletes
Volume 3, Issue 4 , March 2020, , Pages 35-47

https://doi.org/10.22034/HBB.2020.28

Abstract
  In the double-blind study, the effect of drinking Hydrogen-Rich Water (HRW) producing by alkaline stick and tap water (placebo) on 9 male athletes in resistance training during 24 h were studied, and Lactate Dehydrogenase (LDH), Creatine Kinase (CPK) and Lactic Acid (LAC) levels in their blood samples ...  Read More

Iranian biopharmaceutical companies: products and services
Volume 1, Issue 1 , June 2017, , Pages 35-45

https://doi.org/10.22034/HBB.2017.03

Abstract
  Biopharmaceuticals are drugs or vaccines, developed via biotechnology process. Biopharming is production of pharmaceuticals in live organisms. Different platforms can be used for biopharmaceuticals production. Prokaryotes, yeast, fungi, insect cells, mammalian cells, transgenic plants, and transgenic ...  Read More

Biological sciences
Preconditioning with IFN-γ and LPS improves the immunomodulatory potential of bone marrow-derived clonal mesenchymal stem cells

Mehdi Soleymani-Goloujeh; Faezeh Shekari; Seyedeh-Nafiseh Hassani; Ensiyeh Hajizadeh-Saffar

Volume 7, Issue 2 , September 2023, , Pages 35-51

https://doi.org/10.22034/HBB.2023.16

Abstract
  Mesenchymal Stem Cells (MSCs) are one of the promising cellular therapies for immune-related diseases. Preconditioning of MSCs increases their efficacy and overcomes several hurdles in MSC-based therapies. It reduces tissue inflammation and improves cell survival, consequently enhancing therapeutic outcomes. ...  Read More

Treatment of migraine headache with Migracorb, caffeine and ascorbic acid combination
Volume 2, Issue 3 , December 2018, , Pages 36-47

https://doi.org/10.22034/HBB.2018.25

Abstract
  The migraine mechanism; the release of inflammatory neuropeptides, nuclear factor (NF-kB) and proinflammatory proteins leads to increase blood vessel permeability, tissue edema and pain sensitization. From 1989 to 2013 in a single blind randomized clinical trial conducted in Shiraz central hospital, ...  Read More

Formulation and evaluation of mucoadhesive microballons of nizatidine for peptic ulcer
Volume 4, Issue 2 , September 2020, , Pages 37-56

https://doi.org/10.22034/HBB.2020.09

Abstract
  The mucoadhesive microballons were prepared by using combination of polymer-polymer complexation (PAA-PVP) using solvent diffusion method. Mucoadhesive microballons is one of dosage forms which make available the prospectto increase the bioavailability of drug. The prepared delivery system managing the ...  Read More

31P-NMR study for determination of coumarin antifungal mechanism of action
Volume 1, Issue 3 , December 2017, , Pages 37-51

https://doi.org/10.22034/HBB.2017.17

Abstract
  Coumarin derivatives as antifungal bioactive agents have been considered for many years. However, their mechanism of action is not very clear. In the current paper, antifungal activity of natural and synthetic coumarins are studied against Cryptococcus neoformans and Saccharomyces cerevisiae. Mechanism ...  Read More

Antibiotic resistance pattern in Klebsiella pneumoniae strains isolated from children with urinary tract infections from Tabriz hospitals
Volume 4, Issue 1 , June 2020, , Pages 38-45

https://doi.org/10.22034/HBB.2020.03

Abstract
  The aim of this study was to evaluate the resistance pattern and susceptibility of some antibiotics to K. pneumoniae isolated from urinary tract infections. In this descriptive cross-sectional study, 165 K. pneumoniae strains were collected from Tabriz hospitals during six months and were identified ...  Read More

Association of HLA-DRB1*1501-DQA1*0102-DQB1*0602 haplotype in patients with multiple sclerosis in Khuzestan province
Volume 2, Issue 2 , October 2018, , Pages 38-48

https://doi.org/10.22034/HBB.2018.19

Abstract
  The aim of the present study was to reveal a part of genetic profile of multiple sclerosis (MS) in Khuzestan province. The contribution of HLA-DR2 haplotype (HLA-DRB1*1501-DQA1*0102-DQB1*0602) to MS risk is confirmed. This study included 187 MS patients and 192 healthy individuals. HLA alleles were genotyped, ...  Read More

TP53 hotspot mutations in astrocytoma
Volume 2, Issue 1 , July 2018, , Pages 38-45

https://doi.org/10.22034/HBB.2018.13

Abstract
  The aim of this project was to investigate the P53 gene mutations in exon 8 in the patients with astrocytoma type brain tumor. This was an in vitro study, in which the extraction of DNA from 30 samples of brain tissue was performed by phenol-chloroform protocols. After polymerase chain reaction (PCR) ...  Read More

Existence of blaCTX-M, blaSHV and blaTEM genes encoding ESBLs among Escherichia coli isolates from sheep meat products
Volume 3, Issue 1 , June 2019, , Pages 39-44

https://doi.org/10.22034/HBB.2019.11

Abstract
  The aim of this study was investigation of blaCTX-M, blaSHV and blaTEM ESBLs among Escherichia coli (E. coli) isolates from meat products. Fifty sheep meat samples were prepared from some slaughter houses in Tehran, Iran. The isolates were also confirmed by conventional biochemical tests. The antibiotic ...  Read More

Optimization of green synthesis of ZnO nanoparticles by Dittrichia graveolens (L.) aqueous extract
Volume 1, Issue 2 , September 2017, , Pages 39-49

https://doi.org/10.22034/HBB.2017.10

Abstract
  In this work, we reported synthesis of ZnO nanoparticles (ZnONPs) by green procedure. A simple and effective synthesis of ZnONPs was performed by Dittrichia graveolens aqueous extract. The effect of three parameters including pH of the Zinc solution (4.0, 6.0 and 8.0), time (40, 60 and 120 min) and extract ...  Read More

Chemical diversity of essential oil composition from five populations of Dracocephalum Kotschyi Boiss
Volume 5, Issue 1 , June 2021, , Pages 39-50

https://doi.org/10.22034/HBB.2021.10

Abstract
  Composition and chemical variation in the essential oil yield were studied among five wild growing populations of Dracocephalum Kotschyi Boiss. (Lamiaceae) from Iran. The hydrodistilled essential oils were isolated from aerial flowering parts of plant, analyzed by capillary GC-FID (Gas Chromatography ...  Read More

Assessment of cytotoxicity of isolated fractions from the venom of Iranian viper, Macrovipera lebetina on Brain cancer cell line, U-87MG
Volume 3, Issue 2 , September 2019, , Pages 40-51

https://doi.org/10.22034/HBB.2019.16

Abstract
  Brain cancer is the second leading cause of death after leukemia for children. In this study, brain cancer cells (U-87MG) were cultured with 10 % FBS. The Macrovipera lebetina venom was purified by two methods of chromatography. Anti-adhesion and cytotoxic effects were investigated by trypan blue and ...  Read More

Evaluation of common polymorphisms (GTSM1, GSTT1 and GSTP1) in S-glutathione transferase family and susceptibility to basal cell carcinoma (BCC) in Iranian population
Volume 2, Issue 4 , March 2019, , Pages 40-55

https://doi.org/10.22034/HBB.2019.05

Abstract
  The glutathione S-transferase (GST) is a polymorphic supergene family of detoxification enzymes that are involved in the metabolism of potential carcinogens. To evaluate the association between polymorphisms in the GSTs (GSTT1, GSTM1 and GSTP1) and basal cell carcinoma (BCC), 50 BCC patients and 50 healthy ...  Read More