Pharmaceutical sciences
Zahra Salimi; Mohammad Ahmadyousefi
Abstract
Proven RNA-based medications have elevated the demand for targeted nucleic acid-based agents. In this context, nucleic acid aptamers represent an appropriate class of molecules. They are single-stranded nucleic acid molecules that bind to a target molecule with high affinity and specificity. Aptamers ...
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Proven RNA-based medications have elevated the demand for targeted nucleic acid-based agents. In this context, nucleic acid aptamers represent an appropriate class of molecules. They are single-stranded nucleic acid molecules that bind to a target molecule with high affinity and specificity. Aptamers have a number of advantages over antibodies including compact dimenssions, rapid tissue penetration, heat resistance, denaturation resistance, broad spectrum of targets, ease of chemical synthesis, ease of chemical alteration, convenient storage, minimal immunogenic response, negligible variability across batches, and cost-effective production. Here, we discuss whether we can use aptamers to target intracellular antigens and how they could be applied for delivering therapeutics or diagnostic agents to tumor or viral-infected cells. Here, we discuss whether we can use aptamers to target intracellular antigens and how they could be applied for delivering therapeutics or diagnostics to tumor or viral-infected cells.
Pharmaceutical sciences
Soroush Sardari; Setareh Ghavami; Ghazaleh Ghavami; Hassan Toozandehjani
Abstract
Small molecule similarity search as one of the ligand-based virtual screening strategies play a critical role in drug discovery procedures. The current research has been finalized based on the employing interdisciplinary aspects in addition to utilizing skills of cheminformatics in addition to psychosomatic ...
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Small molecule similarity search as one of the ligand-based virtual screening strategies play a critical role in drug discovery procedures. The current research has been finalized based on the employing interdisciplinary aspects in addition to utilizing skills of cheminformatics in addition to psychosomatic facts towards introducing the innovative translator machine system named as TMS-CH for converting small molecule structures to melodic composition and image color combination on the subject of completing inventive pattern and process for chemical structure similarity search. The percentage of true answers for the entire tests among 200 participants confirmed the ability of the proposed TMS-CH system for evaluating the matching level between tested structures. The perception of chemical structures via visual and auditory representations by bio-mimicking human systems during the current investigation can be an efficient strategy to develop findings related to ligand-based similarity search methods.
Biological sciences
Seyed Mohammad Haji Mirghasemi; Hamid Reza Pordeli; Leila Fozouni; Mina Komshikamar; fatemeh komshikamar; Mansoor Rubin
Abstract
A high L-ASNase enzyme production by Bacillus subtilis can hold significant promise as an alternative bacterial source to meet anti-cancer therapies demand. In this study, eight bacterial isolates were obtained from the 35 soil samples of Golestan province, Iran. Samples were collected from different ...
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A high L-ASNase enzyme production by Bacillus subtilis can hold significant promise as an alternative bacterial source to meet anti-cancer therapies demand. In this study, eight bacterial isolates were obtained from the 35 soil samples of Golestan province, Iran. Samples were collected from different soils and cultured in an M9 medium. Enzyme-producing colonies were distinguished by the color change from yellow to pink. 16s rRNA sequencing identified ASNase-producing bacterial species in soil samples. The presence of L-ASNase in Bacillus subtilis was shown by M9 culture and confirmed by spectrophotometry. Bacillus subtilis was identified by 16S rRNA gene sequencing. L-ASNase isolated from Bacillus subtilis showed effective antioxidant activity and also anti-bacterial activity against Staphylococcus aureus and Escherichia coli. The present study demonstrated the presence of L-ASNase-producing Bacillus subtilis strain in soil samples with antioxidant and antibacterial activity.
