Pharmaceutical sciences
A New Frontier: Unveiling the Possibility of Targeting Intracellular Antigens with Nucleic Acid Aptamers

Zahra Salimi; Mohammad Ahmadyousefi

Articles in Press, Accepted Manuscript, Available Online from 20 September 2023

https://doi.org/10.22034/hbb.2023.409781.1105

Abstract
  Proven RNA-based medications have elevated the demand for targeted nucleic acid-based agents. In this context, nucleic acid aptamers represent an appropriate class of molecules. They are single-stranded nucleic acid molecules that bind to a target molecule with high affinity and specificity. Aptamers ...  Read More

Pharmaceutical sciences
Introducing an innovative algorithm based on the abilities of the human perception system towards profiling similarity search of drugs and drug-like compounds: Fluoxetine as an example

Soroush Sardari; Setareh Ghavami; Ghazaleh Ghavami; Hassan Toozandehjani

Articles in Press, Accepted Manuscript, Available Online from 20 September 2023

https://doi.org/10.22034/hbb.2023.387747.1076

Abstract
  Small molecule similarity search as one of the ligand-based virtual screening strategies play a critical role in drug discovery procedures. The current research has been finalized based on the employing interdisciplinary aspects in addition to utilizing skills of cheminformatics in addition to psychosomatic ...  Read More

Biological sciences
Exploring Bacillus subtilis Isolated from Soil as a Promising Alternative for L-Asparaginase Enzyme Production

Seyed Mohammad Haji Mirghasemi; Hamid Reza Pordeli; Leila Fozouni; Mina Komshikamar; fatemeh komshikamar; Mansoor Rubin

Articles in Press, Accepted Manuscript, Available Online from 23 September 2023

https://doi.org/10.22034/hbb.2023.409710.1103

Abstract
  A high L-ASNase enzyme production by Bacillus subtilis can hold significant promise as an alternative bacterial source to meet anti-cancer therapies demand. In this study, eight bacterial isolates were obtained from the 35 soil samples of Golestan province, Iran. Samples were collected from different ...  Read More