Kevin Ricardo Espinosa
Abstract
The approval of the mRNA vaccine technique against COVID-19 opens a door to research and the creation of new drugs against different infectious pathologies or even cancer, since for several diseases the therapeutic options are limited, and different viral diseases They are treated only symptomatically. ...
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The approval of the mRNA vaccine technique against COVID-19 opens a door to research and the creation of new drugs against different infectious pathologies or even cancer, since for several diseases the therapeutic options are limited, and different viral diseases They are treated only symptomatically. For these reasons, this study proposes a hypothesis supported by biological studies, which have been indexed in SciELO, Medline, PubMed and Scopus, in such a way that it provides a theoretical basis for the possible development of a drug that uses the mRNA technique and the ribonucleolytic action of a ribonuclease for a possible antiviral therapy, and analyzes a future perspective of this technique, in order to provide a bibliographic basis on this hypothesis and motivate researchers to carry out biological studies on this topic.
Hendri Busman; Winda Trijayanthi Utama; Rizki Hanriko; Jason Mikail Amper; Indriyani Indriyani
Abstract
Dates have been used to ameliorate various gastrointestinal diseases. This study aimed to evaluate the gastroprotective effect of ajwa dates extract on rats induced by aspirin. Rats were divided into five groups using a completely randomized design. Group 1 received only 300mg/kg BW aspirin. Group 2 ...
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Dates have been used to ameliorate various gastrointestinal diseases. This study aimed to evaluate the gastroprotective effect of ajwa dates extract on rats induced by aspirin. Rats were divided into five groups using a completely randomized design. Group 1 received only 300mg/kg BW aspirin. Group 2 received 25.2mg/kg BW omeprazole and aspirin 300mg/kg BW. Groups 3, 4, and 5 received 250, 500, and 1.000mg/kg BW ajwa dates extract and 300mg/kg BW aspirin, respectively, for 6 hours. At the end of the examination, the average gaster damage score was 1.36, 0.24, 0.96, 0.68, and 0.80, in groups 1, 2, 3, 4, and 5, respectively. The 500 and 1.000 mg/kg BW doses of ajwa dates extract significantly reduced the gaster damage score. It is suggested that the extract of the ajwa date can be utilized as a gastroprotective agent.
TarakaRamarao Ch; Ravali Jami
Abstract
Ezetimibe is a an antihyperlipidemic drug that lowers cholesterol levels.The purpose of this study was to compare different amounts of solid dispersions and formulations using various carriers in order to improve the dissolution. The Design Expert software was used to perform analysis of variance (ANOVA), ...
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Ezetimibe is a an antihyperlipidemic drug that lowers cholesterol levels.The purpose of this study was to compare different amounts of solid dispersions and formulations using various carriers in order to improve the dissolution. The Design Expert software was used to perform analysis of variance (ANOVA), 3D surface plots, counter plots, optimization, and desirability for a two-level factorial. Sun pharma laboratories limited's market product (Ezentia) was compared to the optimised formulation (F6). Results: When compared amount of released was considerably increased using the solid dispersion method. The dissolving characteristics of the improved formulation (F6) and the market tablet were found to be similar, with f1 and f2 values of 11.713 and 99.89. The optimised formula higher on the desire scale (0.72465), indicating a good fit. Conclusion: When the experimental data matched the expected values, the model's predictability and validity were shown.
Helsy Junaidi; Jeanne Adiwinata Pawitan
Abstract
The development of tissue engineering provides various opportunities to engineer various tissues/organs, including vascular tissue engineering. Scaffold plays an essential role in vascular tissue engineering. The selection of biomaterials used as scaffolds will determine the success of vascular tissue ...
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The development of tissue engineering provides various opportunities to engineer various tissues/organs, including vascular tissue engineering. Scaffold plays an essential role in vascular tissue engineering. The selection of biomaterials used as scaffolds will determine the success of vascular tissue engineering. The structure of vascular system, which consists of three layers, is embedded in extracellular matrices that provide the mechanical properties of the system. Therefore, tissue engineering of a vascular structure needs various suitable biomaterials as scaffold that can support vascular system mechanical properties and function. Various materials were used for 3D printing and electro-spinning with good results, including collagen, gelatin, and alginate. In conclusion, the varying sizes of blood vessels require scaffolds with biomaterials that can adapt to their shape, size and approximate the mechanical properties of the blood vessels. Various biomaterials are suitable to produce scaffolds for vascular engineering.
