Telomere shortening occurs in patients with ectodermal dysplasia
Volume 4, Issue 4 , March 2021, , Pages 1-5

https://doi.org/10.22034/HBB.2021.01

Abstract
  Ectodermal Dysplasia (ED) is a rare congenital disorder that is characterized by sparse hair, lack or absence of sweat glands, and rod-shaped teeth, which are diagnosed by two or three of these features. There are approximately 200 subtypes of ED have been identified. One of the rare and severe subtypes ...  Read More

The combination effects of theophylline and corticosteroids in COVID-19
Volume 4, Issue 3 , December 2020, , Pages 1-5

https://doi.org/10.22034/HBB.2020.13

Abstract
  Late in 2019, the novel coronavirus disease (COVID-19) became pandemic. The disease has associated with severe inflammatory symptoms of the respiratory epithelial cells and the dysfunction of several organs of the body. Studies have shown that theophylline plays an important role in acute inflammation ...  Read More

Pathogenesis, significant biomarkers and treatment strategies in ovarian cancer
Volume 4, Issue 2 , September 2020, , Pages 1-27

https://doi.org/10.22034/HBB.2020.07

Abstract
  The aim of this paper is to study the pathogenesis, significant biomarkers and treatment strategies in ovarian cancer. Because of poor prognosis, ovarian cancer is usually diagnosed in final stages and although the first phase of treatment and chemotherapy usually seems to be a nice therapeutic approach ...  Read More

Drug repurposing against COVID-19 by GWAS
Volume 4, Issue 1 , June 2020, , Pages 1-6

https://doi.org/10.22034/HBB.2020.01

Abstract
  This note is prepared by the authors of a recent publication on shared genetic architecture of drug response based on summary statistics from genome-wide association studies (GWAS) to propose a drug repurposing approach for the treatment of coronavirus COVID-19. The authors proposed that in silico studies ...  Read More

Spirulina, food of past, present and future
Volume 3, Issue 4 , March 2020, , Pages 1-20

https://doi.org/10.22034/HBB.2020.26

Abstract
  Spirulina is a multicellular and filamentous blue-green microalgae. Its contains large amounts of protein (70 % dry weight), carotenoid (4000 mg/kg),omega-3 and omega-6 polyunsaturated fatty acids, Gamma Linoleic Acid (GLA), sulfolipids, glycolipids, polysaccharides, provitamins; vitamin A, vitamin E, ...  Read More

Cytopenia in Influenza and possible treatment strategies (Drug and Vaccine)
Volume 3, Issue 3 , December 2019, , Pages 1-11

https://doi.org/10.22034/HBB.2019.20

Abstract
  Viruses consistently present a major health danger and require a proper, balanced reaction from our immune system. Among viruses, human influenza viruses often cause morbidity and mortality, especially in populations at high risk. These viruses cause apoptosis in peripheral blood monocytes and tissue ...  Read More

The synergistic effect of probiotic bacteria and medicinal plants in Iran
Volume 3, Issue 2 , September 2019, , Pages 1-15

https://doi.org/10.22034/HBB.2019.14

Abstract
  The clinical studies proved the antimicrobial synergistic effect of probiotic bacteria and medicinal plants. In addition, this synergic effect can help to maintain food and prevent food corruption. There are plenty of pharmaceutical-probiotic products in the world and offering the same products in Iran ...  Read More

Venom allergens in the venom of venomous animals
Volume 3, Issue 1 , June 2019, , Pages 1-8

https://doi.org/10.22034/HBB.2019.07

Abstract
  Today allergens are known as molecules that induce an IgE-mediated reaction (allergy) in human beings. Protein is one of the most important molecules that could be the allergen. Allergens sources are varied from plants, animals, and fungi to microbial and even viral sources. Melittin, phospholipase A2, ...  Read More

Design and computational analysis of a derivative of camptothecin
Volume 2, Issue 4 , March 2019, , Pages 1-10

https://doi.org/10.22034/HBB.2019.01

Abstract
  Camptothecin (CPT) as anti-tumor quinoline alkaloid drug is demonstrated. In this research, a derivative of camptothecin, Diol camptothecin, was designed. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties were computed to achieve appreciate bioavailability and computational ...  Read More

XylA, a signal peptide for periplasmic expression of human growth hormone in Escherichia coli
Volume 2, Issue 3 , December 2018, , Pages 1-11

https://doi.org/10.22034/HBB.2018.22

Abstract
  Most of proteins produced in Escherichia coli accumulate as insoluble inclusion bodies. Optimal secretion of the recombinant protein can be obtained by a desirable signal peptide .In this research, we used Bacillus. sp endoxylanase signal peptide in order to guide the human growth hormone (HGH) to the ...  Read More

A role of telomerase in cancer progression and therapeutic program for anti-telomerase approach and future objectives
Volume 2, Issue 2 , October 2018, , Pages 1-13

https://doi.org/10.22034/HBB.2018.15

Abstract
  Typically, the length of the telomeres is shortened at each time of cell division, which can induce chromosomal instability. In many tumor cells, telomere lengths are maintained by an enzyme called telomerase, which is a mechanism for starting and surviving tumors. The human telomerase reverse transcriptase ...  Read More

Three species of main bacteria in treatment of cancer
Volume 2, Issue 1 , July 2018, , Pages 1-3

https://doi.org/10.22034/HBB.2018.08

Abstract
  Cancer is identified by uncontrolled growth of cells. These cells may spread to other parts of the body, and this is called metastasis. Bacterial treatment is a new idea in the world. In this hypothesis, three species of bacteria in treatment of cancer were introduced.  Read More

Effect of electric and magnetic fields on biological systems
Volume 1, Issue 4 , March 2018, , Pages 1-18

https://doi.org/10.22034/HBB.2018.01

Abstract
  Nowadays, due to the growth of science and technology in various fields and human intervention and application of electrical energy in everyday life have led to the fact that electric and magnetic fields are considered as one of the constituents of the environment and destructive effects of these waves ...  Read More

Pharmacy informatics: A reform at drug consumption management in healthcare
Volume 1, Issue 3 , December 2017, , Pages 1-4

https://doi.org/10.22034/HBB.2017.23

Abstract
  In recent decades, since the pharmacy has a key role in patient care, advancement in information technology has created many opportunities for pharmacists and pharmacies to leverage informatics to support their practice and improve care.  Read More

Early detection of melanoma with synchrotron radiation X-ray fiber diffraction analysis
Volume 1, Issue 2 , September 2017, , Pages 1-4

https://doi.org/10.22034/HBB.2017.22

Abstract
  Skin is the largest organ in our body protecting us from ultraviolet radiation and xenobiotics. The function of keratinocytes is to form the impermeable barrier for the skin and rest of the body, whereas melanocytes provide the pigment for the keratinizing skin layers to protect the integrity of keratinocytes, ...  Read More

Formatted journals
Volume 1, Issue 1 , June 2017, , Pages 1-2

https://doi.org/10.22034/HBB.2017.21

Abstract
  In order to achieve new generation of academic journals available to scientists, a crossword puzzle like application which is capable of finding a right path to publication of data and information is needed. These applications should have the capability for editing papers by highly qualified people by ...  Read More

Association of interleukin-10 gene promoter variants with ischemic stroke among the Pakistani population
Volume 5, Issue 1 , June 2021, , Pages 1-14

https://doi.org/10.22034/HBB.2021.07

Abstract
  Genetic variations in Interleukin-10 (IL-10), an anti-inflammatory cytokine, has the potential to influence the development of Ischemic Stroke (IS). The current study aimed to examine IL-10 gene polymorphisms (rs1800896, rs1800871 and rs1800872) in association with IS. After genotyping, associational ...  Read More

New insights into the effects of hydroxychloroquine in COVID-19
Volume 5, Issue 2 , September 2021, , Pages 1-6

https://doi.org/10.22034/HBB.2021.13

Abstract
  In late 2019 until 2021, the novel coronavirus disease (COVID-19) has become pandemic. This disease is related to severe inflammatory symptoms of the respiratory epithelial cells and the dysfunction of several organs. One of the suggested drugs to reduce the inflammation caused by COVID-19 is hydroxychloroquine. ...  Read More

Novel target of the 4-piperidone thiazole derivative for platelet inhibitions by using inducers collagen and ADP
Volume 5, Issue 3 , December 2021, , Pages 1-16

https://doi.org/10.22034/HBB.2021.19

Abstract
  Platelets are thought to aid in hemostasis, thrombosis, inflammation, wound healing, and immunity. R4 is a novel thiazole derivative that may decrease angina and ischemia. An aggregometer evaluated R4 impact on PRP. Spectrophotometric method measured anti-lipoxygenase activity of R4. In its absence, ...  Read More

Biological sciences
Inflammation and Colorectal Cancer: The Bioinformatics Analysis of Multifunctional Role of Microbiota and Diet in Colorectal Cancer Development

Mohammad Ali Pahlevan Neshan; Payam Shahnazi Gerdehsang; Ahmad Bereimipour; Nazila Bostanshirin; Haniyeh Sadat Hosseininia; Kaykhosro Moridi; Amin Ebrahimi Sadrabadi; Arsalan Jalili

Volume 5, Issue 4 , March 2022, , Pages 1-25

https://doi.org/10.22034/HBB.2022.01

Abstract
  Chronic inflammation in colorectal cancer can result in the progression of tumorigenesis. Inflammation in the colorectal part of the body can be affected by microbiota, as well as an individual diet. These two factors play a critical role in cancer types related to the colon and rectum. This inflammation ...  Read More

Medicinal sciences
Biomechanics and neurochemical changes to predict the effect of traumatic brain injury

Jeanne Adiwinata Pawitan; Corry Novita Mahama

Volume 6, Issue 1 , June 2022, , Pages 1-12

https://doi.org/10.22034/HBB.2022.07

Abstract
  Traumatic Brain Injury (TBI) can occur when the head suddenly hits an object and the internal forces produce damage to the brain, disrupting its normal function, with or without structural changes. TBI causes disability and death to almost all age groups. This review aimed to describe the biomechanics ...  Read More

Carbon quantum dots may interfere with colorectal cancer treatment through affecting on glutamine metabolism

Mohadeseh Nemati; Fahima Danesh Pouya; Fateme Zarein; Mahdieh Nemati; Yousef Rasmi; Jafar Rezaie; Tooba Hallaj

Volume 6, Issue 2 , September 2022, , Pages 1-5

https://doi.org/10.22034/HBB.2022.13

Abstract
  Cancer cells are metabolically different from normal cells, including the Warburg effect and uses glutamine to fill the Tricarboxylic Acid (TCA) cycle. It was demonstrated inhibiting glutamine metabolism prevents tumor growth. The mammalian Target of Rapamycin (mTOR) is one of the signaling pathways ...  Read More

Introduction of CRISPR/Cas system, as a genetic interference pathway and essential factor in genome evolution
Volume 1, Issue 1 , June 2017, , Pages 3-23

https://doi.org/10.22034/HBB.2017.01

Abstract
  The clustered regularly interspaced short palindromic repeats / (CRISPR) associated protein system is an adaptive immune system in bacteria and archaea. This system mimics eukaryotic RNA interference (RNAi) system and can play an important role in gene regulation and immune system. CRISPR interference ...  Read More

Heme extract from horseradish peroxidase to use as nanomedicine for porphyria
Volume 2, Issue 1 , July 2018, , Pages 4-11

https://doi.org/10.22034/HBB.2018.09

Abstract
  Porphyria is a group of autosomal metabolic disorders which is characterized by genetic defects in heme biosynthesis pathway enzymes. The symptoms of the porphyria occur almost due to excess amount of heme precursors. Heme is a prosthetic group of hemoproteins including hemoglobin and essential enzymes ...  Read More

The role of G9a gene in various cancers
Volume 1, Issue 3 , December 2017, , Pages 5-11

https://doi.org/10.22034/HBB.2017.14

Abstract
  G9a is an epigenetic regulator that methylate the lysine 9 of histone 3 and has a role in gene silencing. G9a generally causes repression of gene expression and participates in diverse cellular functions such as DNA repairing, proliferation and differentiation. This gene is overexpressed in some types ...  Read More