2024-03-29T19:52:44Z
https://www.healthbiotechpharm.org/?_action=export&rf=summon&issue=18113
Health Biotechnology and Biopharma (HBB)
HBB
2019
3
3
Cytopenia in Influenza and possible treatment strategies (Drug and Vaccine)
Viruses consistently present a major health danger and require a proper, balanced reaction from our immune system. Among viruses, human influenza viruses often cause morbidity and mortality, especially in populations at high risk. These viruses cause apoptosis in peripheral blood monocytes and tissue culture cells. Hemophagocytosis-induced pancytopenia has also been frequently correlated with the newly emerging influenza virus infection in latest years. Leukopenia, particularly in influenza B virus, has been discovered to be a common finding in influenza infection. If the virus and the resulting antiviral reaction continue, the inflammatory feedback on the hematopoietic system becomes chronic. Here, we have reviewed effect of Influenza on hematological factors specially cytopenia.
Influenza virus
Hematological factors
cytopenia
2019
12
01
1
11
https://www.healthbiotechpharm.org/article_133306_c1b79c75f218ab68b4f65dcc6ad07d3f.pdf
Health Biotechnology and Biopharma (HBB)
HBB
2019
3
3
A novel approach for analysis of shared genetic architecture of drug response based on summary statistics from genome-wide association studies
The main objective of this study is to gain an exploratory sense of the relationships between the phenotypes (response to drugs) employing the genome‐wide association studies (GWAS) summary statistics for searching underlying contribution of pleiotropy across the associated SNPs to this relationship. The findings in this study show that the effect size should be weighted appropriately, depending on the nature of assumption made for conducting phenotype clustering based on GWAS summary. Thus the methods used were helpful for exploring workable clusters of related drugs on the basis of the effect size of the shared associated SNPs when weighted with SNP-sharing strength. The presence of strong correlation between the weighted fixed effect size and the principal components provides a possibility of using principal component regression for predicting the effect size of association of a drug response with SNPs. Overall, the phenotypic pattern of drugs and associated SNPs revealed by this study are expected to help in future for understanding aetiological basis of different drugs by highlighting relevant biological pathways.
Genome‐wide association studies
cross-phenotype associations
effect size
2019
12
01
12
49
https://www.healthbiotechpharm.org/article_133307_8fbd7852642edc0739b1ddad8dae524d.pdf
Health Biotechnology and Biopharma (HBB)
HBB
2019
3
3
Importance of the catalytic site neighbouring residues on the functionality of the enzymes
Catalytic residues are highly conserved among the proteins, amino acid residues which are sequentially neighbor to the catalytic sites, some extent contain similar structural information. Collected data from the Protein Data Bank (PDB) database contain one aspartic protease group (n=28) and two serine protease groups (n=37 and n=7) specified by catalytic triads. Analysis of the molecular structures of amino acids by Sparse Linear Discriminant Analysis (SLDA) and t-test revealed that the neighbor residues contain information on the functional differentiation of the enzymes, suggesting that the sequentially close residues to the catalytic triads are more preserved than the rest of amino acid residues. Moreover, similar structural properties in the vicinity of all three catalytic sites can be observed by correlation heat maps. These results can hopefully facilitate a better understanding of the protein function from structure and lead to novel protein design.
Catalytic residues
active sites
sequence conservation
enzyme function
2019
12
01
50
58
https://www.healthbiotechpharm.org/article_133308_ff18918712f72030553e402899fdc1bc.pdf
Health Biotechnology and Biopharma (HBB)
HBB
2019
3
3
Chemotherapy, dialysis and transplantation analysis among immunocompromised patients with focus on tuberculosis, syphilis, hepatitis B, C, HIV and chicken pox
Immunodeficiency cases are a common cause of hospital deaths in hospitalized patients. Given the high prevalence of nosocomial deaths due to infection in immunocompromised patients, we aimed to evaluate Tuberculosis (TB), syphilis, hepatitis B and C, HIV and chickenpox in hospitalized immunocompromised patients, dialysis and Transplantation analysis of Shahid Sadoughi Hospital in 2017. This study was a descriptive cross-sectional study. The study population consisted of 100 patients with immunodeficiency admitted in chemotherapy, dialysis and transplantation wards of Yazd Shahid Sadoughi Hospital in 2017. Based on the obtained results, it could be concluded that HIV Ab, HCV Ab and HBS Ag tests are more prevalent in immunocompromised patients.
Immunodeficiency Patients
dialysis
Transplantation
Chemotherapy
2019
12
01
59
68
https://www.healthbiotechpharm.org/article_133309_ba3d23158d0f26ba7cf390662ad990de.pdf
Health Biotechnology and Biopharma (HBB)
HBB
2019
3
3
Frequency and antibiotic resistance pattern of the clinical isolates of extended spectrum beta Lactamase producing Escherichia coli from the blood specimens in hospitals and medical centers in Tabriz, Iran
Production of Extended Spectrum Beta Lactamase (ESBL) enzymes is one of the main reasons for drug resistance in Escherichia coli (E. coli) isolates. The aim of this study was to determine the ESBL producing E. coli isolates in the blood culture of patients in hospitals and medical centers in Tabriz, Iran. In this descriptive cross-sectional study, 200 isolates of E. coli from blood specimens in hospitals and medical centers were investigated from December 2018 to May 2019. The production of ESBLs was confirmed using the combined disc method and antimicrobial susceptibility test. Out of 200 isolates, 100 isolates (50 %) were able to produce ESBL. The highest antibiotic resistance of isolates (100 %) was to ceftriaxone, cefotaxime, cefixime and cefuroxime. The highest antimicrobial susceptibility was also observed to amikacin (12 %), meropenem (6 %) and imipenem (2 %), respectively. The results of this study showed the high resistance of E. coli isolates especially ESBL producing strains to different antibiotics. Given the relatively high prevalence of the ESBL producing E. coli strains and their resistance to common antibiotics, effective control strategies such as the restricted use of broad spectrum cephalosporins should be implemented.
Escherichia coli
Antibiotic resistance pattern
Extended Spectrum Beta Lactamases
2019
12
01
69
78
https://www.healthbiotechpharm.org/article_133310_c29b7a2878b722c5ec677bffbfceb7f6.pdf
Health Biotechnology and Biopharma (HBB)
HBB
2019
3
3
Fabrication of ketoconazole nanosuspention, by pearl milling technique and evaluation, characterization of nanocrystals prepared
In the present study, ketoconazole nanosuspentoin were prepared in order to increase solubility by pearl milling technique via solution include Tween 60 and polyvinylpyrrolidone K30 (PVP K30). The Ketoconazole and the resulting ketoconazole nanosuspention were characterized by Fourier-Transform InfraRed spectroscopy (FT-IR) and Differential scanning calorimetry (DSC) analysis. The Atomic force microscopy (AFM) analysis indicated the formation of homogenous and spherical nanosuspention with the final average particle size of around 113.7 nm. Finally the solubility test has shown that ketoconazole nanosuspention solubility has increased.
Ketoconazole
nanosuspention
pearl milling
poor solubility
nanodrug
2019
12
01
79
89
https://www.healthbiotechpharm.org/article_133312_8ed295cd7780674dc24fd8cddb486d04.pdf