TY - JOUR ID - 166945 TI - One pot, green synthesis and biological evaluation of some isatin-based thiocarbohydrazones derivatives JO - Health Biotechnology and Biopharma (HBB) JA - HBB LA - en SN - AU - Shahcheragh, Seyyed Mohammad AU - Habibi, Azizollah AU - Shirzad, Masoomeh AU - Farahani, Yekta AU - Sardari, Soroush AD - Faculty of Chemistry, Kharazmi University; Tehran, Iran AD - Drug Design and Bioinformatics Unit, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran; Tehran, Iran Y1 - 2023 PY - 2023 VL - 6 IS - 4 SP - 81 EP - 97 KW - Hiocarbohydrazone KW - Deep eutectic solvent KW - one pot and three-component condensation reaction DO - 10.22034/HBB.2023.07 N2 - In the present study, a one-pot, green and three-component route for synthesis of Thiocarbohydrazone (TCS) derivatives is described. This reaction was performed in choline chloride/urea (1:2) as Deep Eutectic Solvent (DES). The structures were characterized by FTIR, 1H NMR, 13C NMR spectra and elemental analysis. The derivatives were evaluated for their anti-mycobacterial activity against Mycobacterium bovis BCG, and the results revealed that among the synthesized compounds (1a-1h, 2a-2h, 3a-3h), 3b, 3c and 1b exhibited the highest activity with MIC value of 7.81 and 11.71 μg/mL. Additionally, the target compounds were evaluated for their anti-microbial activity against E.coli and Candida Albicans and the result indicated that in contrast to the low antifungal activity, the produced derivatives with electron-withdrawing substitution at the ortho, meta and para positions of benzyl ring includes 1d, 2b and 3d-3g demonstrated remarkable anti-micobacterial activities. UR - https://www.healthbiotechpharm.org/article_166945.html L1 - https://www.healthbiotechpharm.org/article_166945_fe9a9bab6851efc292171c25d306dd3e.pdf ER -