%0 Journal Article %T Specific signaling pathways and drugs play key role in regulation of angiogenesis %J Health Biotechnology and Biopharma (HBB) %I Health Biotechnology and Biopharma %Z 2538-4414 %D 2020 %\ 06/01/2020 %V 4 %N 1 %P 7-37 %! Specific signaling pathways and drugs play key role in regulation of angiogenesis %K signaling pathway %K Angiogenesis %K cancer regulation %K inducers %R 10.22034/HBB.2020.02 %X In this study, angiogenesis inducers and inhibitors and some important drugs are introduced. Abnormal angiogenesis can occur if the balance between inhibitory and inducible factors disappears. Angiogenesis inducers include EGF, FGF2, TGF-β, VEGF, G-CSF, HGF, TGF-α, IL-8, TNF-α and angiogenesis inhibitors such as endostatin, interleukin, prolactin, interferons, IL-1, IL-12, angiostatin, and IL-18. On the other hand, many drugs can affect these signaling pathways. %U https://www.healthbiotechpharm.org/article_133124_515309d6beb8abc5a908768577585b1a.pdf