@article { author = {}, title = {Effect of electric and magnetic fields on biological systems}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {1}, number = {4}, pages = {1-18}, year = {2018}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2018.01}, abstract = {Nowadays, due to the growth of science and technology in various fields and human intervention and application of electrical energy in everyday life have led to the fact that electric and magnetic fields are considered as one of the constituents of the environment and destructive effects of these waves have increased on the health of human and other creatures. In fact, these fields have harmful effects on biological structure of human tissues. In this study, the electromagnetic fields and the reduction of radiation were evaluated on animals and human.}, keywords = {Electrical and magnetic fields,biological structure,Environment,Human Health}, url = {https://www.healthbiotechpharm.org/article_133679.html}, eprint = {https://www.healthbiotechpharm.org/article_133679_da52612a31683cc15f73eac608363daf.pdf} } @article { author = {}, title = {Evaluation of industrial cosmetic products and replacing them with natural products according to modern, traditional and islamic medicine}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {1}, number = {4}, pages = {19-31}, year = {2018}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2018.02}, abstract = {Nowadays, cosmetic products are used excessively and there are cosmetic products in daily shopping basket of women. One of the public health issue is the possibility of transmission of pathogens by cosmetic products which are not standard and lead to an increase in the risk of various skin diseases and heavy metal toxicities. Herbs are important in traditional, modern cosmetic industries. Consumption of cosmetic products is common among different society. In the past years, the natural products such as Lamiaceae were used for cosmetic purposes. In Islamic medicine signs of usage of natural products for health purposes can be found such as Cedrus Libani, Allium sativum, Punica granatum. In modern medicine, plants such as Aloe vera are used in cosmetics. The use of cosmetics is a part of life for human society. Based on importance of natural products in traditional medicine and also most of the cosmetic products in the market are made of herb extracts and natural components, more attention should be paid to this issue.}, keywords = {Cosmetic products,traditional medicine,Natural products,Medical plants}, url = {https://www.healthbiotechpharm.org/article_133680.html}, eprint = {https://www.healthbiotechpharm.org/article_133680_4ceb7ecb83a55db5140b8059d86932dc.pdf} } @article { author = {}, title = {Biochemical evaluation of antioxidant activity, phenol and flavonoid contents of Dracocephalum Kotschyi Boiss extracts obtained with different solvents}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {1}, number = {4}, pages = {32-44}, year = {2021}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2018.03}, abstract = {Dracocephalum Kotschyi Boiss, is one of Dracocephalum species which has been used in traditional Iranian medicine with pharmacological and biological activities. The antioxidant properties and total flavonoid and phenolic contents of three different extracts of Dracocephalum Kotschyi Boiss were investigated. The antioxidant activity of the extracts was calculated using three different assay including DPPH (2,2-diphenyl-1-picrylhydrazyl), FRAP (ferric reducing ability of plasma) and ABTS (2,2ʹ-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)). Among these extracts, the methanol extracts showed the highest radical scavenging activity 6.87±0.01 μmoL Trolox/g ferric reducing activity and the best activity in ABTS test (7.47±0.03 μmoL Trolox/g). The methanol extract of Dracocephalum Kotschyi showed also the highest total phenolic content 188.08±0.01 mg GAE/g, followed by ethyl acetate extract 95.58±0.01 mg GAE/g and also greatest total flavonoid content with 1037.00±0.01 mg quercetine equivalents/g. The results of this study showed that the potent antioxidant activity of Dracocephalum Kotschyi make use it as a natural antioxidant in food industries and other pharmaceutical purposes.}, keywords = {Dracocephalum Kotschyi Boiss,FRAP,ABTS,DPPH,Total Phenol,Flavonoid content}, url = {https://www.healthbiotechpharm.org/article_133682.html}, eprint = {https://www.healthbiotechpharm.org/article_133682_73367b12351bbaa15b270b05dd873eff.pdf} } @article { author = {}, title = {Constituents and antimicrobial activity of the volatile oils from different parts of Nepeta gloeocephala}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {1}, number = {4}, pages = {45-55}, year = {2018}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2018.04}, abstract = {In this study, we identified the chemical composition and antimicrobial effects of different parts of essential oils of Nepeta gloeocephala. Totally 65 volatile compounds from the essential oils in N. gloeocephala were obtained by means of hydrodistillation and its components were analyzed using GC and GC-MS. These compounds are mainly oxygenated monoterpenes, monoterpene hydrocarbons and oxygenated sesquiterpenoids compound. The antimicrobial activity of leaf, flower, stem and root essential oils from N. gloeocephala were studied against seven gram-positive and gram-negative bacteria and two fungi by the disc diffusion method. The results of the bio assays showed an interesting antimicrobial activity, in which the gram-positive bacteria, Bacillus cereus and Staphylococcus aureus, were the most sensitive to the oils, as well the oils exhibited a remarkable antifungal activity against all the tested fungi.}, keywords = {Nepeta gloeocephala,Essential oil,Antimicrobial,Chemical composition}, url = {https://www.healthbiotechpharm.org/article_133684.html}, eprint = {https://www.healthbiotechpharm.org/article_133684_d90c8f768beebcda4221b240eb193c46.pdf} } @article { author = {}, title = {Effect of aqueous extract of Quercus Infectoria gall on the basic contractility, frequency and strength of isolated virgin rat uterus smooth muscle}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {1}, number = {4}, pages = {56-65}, year = {2018}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2018.05}, abstract = {Myometrial contractions have important role in physiological processes such as sperm and embryo transport, implantation, uterus retraction and reducing post-partum hemorrhage. Quercus infectoria (Aleppo oak) is well-known since ancient times as an astringent agent. In the present study, the cumulative effect of the aqueous extract of Quercus. infectoria gall (Qig) on the frequency, strength and basic uterine smooth muscle contractility of virgin rats were studied and its contractile effect compared to acetylcholine. This experimental study was carried out on 12 strips taken from the middle part of the uterine of rats (wistar, weight 200-250 g). In the experiments, the cumulative effect of the aqueous extract of Qig on the activity of rat uterine muscle was studied. The cumulative effect of different concentrations of the aqueous extract of Qig significantly increased the contractile response of uterine smooth muscle in a dose-dependent manner. This effect was less than the acetylcholine effect. The aqueous extract of Qig could have potentials for the treatment of disorders associated with low myometrial contractions such as post-partum hemorrhages. In this study, we have proved the high potential of the Qig extract on phasic contraction activity of rat uterus and also the effective dose of extract was identified.}, keywords = {aqueous extract,isolated tissue,Quercus infectoria gall,Rat,uterus smooth muscle}, url = {https://www.healthbiotechpharm.org/article_133685.html}, eprint = {https://www.healthbiotechpharm.org/article_133685_77c16be0a49b1db508fdc437ca819b1e.pdf} } @article { author = {}, title = {Bioinformatics progress in Iran}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {1}, number = {4}, pages = {66-71}, year = {2018}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2018.06}, abstract = {Bioinformatics students should recognize their situation to their world. Today, we have a huge amount of publically available data that are yet to be analyzed. There is a big gap between the analyzed and well-understood data and the raw data. A bioinformatics researcher can play an important role in fixing this gap. They should consider the importance of their field and really focus on interdisciplinary education, to be effective both on the biomedical side and the computational side. On the other hand, I strongly recommend biology and medical students not to remain simple bioinformatics end users. I invite them to push themselves to learn more about the mathematics and computer science behind algorithms. On the other hand, I urge the informatics students to study the language and the methodology of biology and biomedicine. In conclusion, I invite them to pay attention to the biology.}, keywords = {Bioinformatics,biology,Iran}, url = {https://www.healthbiotechpharm.org/article_133688.html}, eprint = {https://www.healthbiotechpharm.org/article_133688_1f0780939e2d5e6667c76cf8540741e0.pdf} } @article { author = {}, title = {Aqueous extract of Nigella sativa L suppress proinflamatory cytokine gene expression}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {1}, number = {4}, pages = {72-82}, year = {2018}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2018.07}, abstract = {Due to the side effects of current therapies for osteoarthritis one of the alternative medicine is using herbal medicine such as Nigella sativa L. We examined that alcoholic extract of Nigella sativa (AENS) has an anti-inflammatory activity. Cells were activated with 100 ng/ml lipopolysaccharide for 24 h and cell supernatants were analyzed for PGE2 and nitrite content. One set of cells was activated for 1 h with LPS (100 ng/ml) for both reverse-transcriptase PCR and real-time PCR analysis of TNF-a, IL-1b , COX-2, and iNOS expression. AENS also reduced TNF-α and IL-1b expression in LPS-activated THP-1 cells. The present study demonstrates that the anti-inflammatory activity of AENS is not restricted to synoviocytes, but also affects monocyte macrophage-like cells that serve as a prototype for macrophages in the synovial membrane. These observations provide a scientific rationale for the pain-reducing and anti-inflammatory effects of AENS observed in osteoarthritis patients.}, keywords = {Nigella sativa .L,bovine fibroblast-like,osteoarthritis,proinflammatory cytokine}, url = {https://www.healthbiotechpharm.org/article_133690.html}, eprint = {https://www.healthbiotechpharm.org/article_133690_1082ff9958acb6464e4885ff1520ee97.pdf} }