@article { author = {}, title = {Three species of main bacteria in treatment of cancer}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {2}, number = {1}, pages = {1-3}, year = {2018}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2018.08}, abstract = {Cancer is identified by uncontrolled growth of cells. These cells may spread to other parts of the body, and this is called metastasis. Bacterial treatment is a new idea in the world. In this hypothesis, three species of bacteria in treatment of cancer were introduced.}, keywords = {cancer,Bacteria,treatment,Listeria monocytogenes}, url = {https://www.healthbiotechpharm.org/article_133495.html}, eprint = {https://www.healthbiotechpharm.org/article_133495_5977c06e679028330e2b42a68996b0d7.pdf} } @article { author = {}, title = {Heme extract from horseradish peroxidase to use as nanomedicine for porphyria}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {2}, number = {1}, pages = {4-11}, year = {2018}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2018.09}, abstract = {Porphyria is a group of autosomal metabolic disorders which is characterized by genetic defects in heme biosynthesis pathway enzymes. The symptoms of the porphyria occur almost due to excess amount of heme precursors. Heme is a prosthetic group of hemoproteins including hemoglobin and essential enzymes such as peroxidase. It is illustrated that the heme molecule in horseradish peroxidase has a remarkable similarity to the one in human hemoglobin. In this hypothesis, we suggested that heme molecules extracted from horseradish peroxidase as a substitutional plant source, will be effective in heme deficiency disorders such as porphyria. So, heme derivatives could be regarded as a drug in order to regulate the excess heme production. It is also hypothesized that in order to maintain the heme molecules in an intact form and prevent from intestinal degradation, it could be conjugated with nanoparticles such as polylactic-co-glycolic acid (PLGA).}, keywords = {heme,Horseradish peroxidase,nanomedicine,porphyria}, url = {https://www.healthbiotechpharm.org/article_133497.html}, eprint = {https://www.healthbiotechpharm.org/article_133497_b11a238e6226782df8bd145f2bd0b5d7.pdf} } @article { author = {}, title = {An in silico study to find angiogenesis inhibitory role for Naja oxiana snake venom cytotoxins}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {2}, number = {1}, pages = {12-20}, year = {2018}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2018.10}, abstract = {Cytotoxins especially CTX-I and CTX-II are components in the venom of cobra snakes. Cytotoxins as apoptotic agents are appropriate candidates to study of anticancer drugs. In this study we performed docking analysis of CTX-I and CTX-II against vascular endothelial growth factor (VEGF) and its main receptor (VEGFR2) that are the main key factors of angiogenesis. The results showed that CTX-I has higher binding affinity to VEGF and VEGFR2 compare to its native ligand, so it could be a suitable candidate to study anticancer drug.}, keywords = {cytotoxin,Venom,Naja oxiana snake}, url = {https://www.healthbiotechpharm.org/article_133498.html}, eprint = {https://www.healthbiotechpharm.org/article_133498_3d946014162ee8b91edbf90dbd534268.pdf} } @article { author = {}, title = {Examining of the quality and quantity of active ingredients of Smirnova iranica Sabeti in different habitats}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {2}, number = {1}, pages = {21-27}, year = {2018}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2018.11}, abstract = {In this study, four sites were chosen in the habitat of the plant which are located in Kashan. In order to complete phytochemical studies during flowering in each site, leaves were collected and after extraction of essential oils by simultaneous method of distillation and extraction using organic solvents, an analytical chromatography connected to a mass spectrometer (GC/MS) was used to identify the ingredients of essential oils. The results of the efficiency of leaves showed in different sites that the highest quantity belonged to the samples taken from sites 2 and 4. Comparison of essential oil compounds showed that the main compounds identified in all the leaf samples from all sites were compounds such as hexadecanoic acid.}, keywords = {Medicinal plant,tetradecanoic acid,Kashan,GC/MS}, url = {https://www.healthbiotechpharm.org/article_133499.html}, eprint = {https://www.healthbiotechpharm.org/article_133499_c867ef93f3ba7ce0a8cbfcbe1205d905.pdf} } @article { author = {}, title = {Study of drug resistance pattern of Pseudomonas aeroginosa at Shahid Sadoughi and central laboratories of Yazd in Iran}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {2}, number = {1}, pages = {28-37}, year = {2018}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2018.12}, abstract = {This research aims to assess drug resistance pattern of Pseudomonas aeroginosa. This study cross-sectional was done on 151 positive culture tests of P. aeroginosa from May 2016 until May 2017 in Shahid Sadoughi and central laboratories of Yazd. In this study the sensitivity was evaluated according to the type of antibiotics and then according to location of sampling, type of the specimen and type of reception. The bacteria had most sensitivity to colistin (92.8 %) and then tobramycin (74.2 %). Also the most resistance was to ceftriaxone (70.4 %). The rate of the bacterial resistance to some types of antibiotics was as follow: cefotaxime (64%), ceftazidime (33.1 %), ciprofloxacin (30.3 %) and meropenem (27.5 %). There were not significant differences between antibiotic sensitivities according to the type of specimen while there were significant differences between antibiotic sensitivities based on the location of clinic.}, keywords = {Pseudomonas aeroginosa,Resistance,Yazd}, url = {https://www.healthbiotechpharm.org/article_133502.html}, eprint = {https://www.healthbiotechpharm.org/article_133502_453f099a7d41443fe062de1d26e1ff6e.pdf} } @article { author = {}, title = {TP53 hotspot mutations in astrocytoma}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {2}, number = {1}, pages = {38-45}, year = {2018}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2018.13}, abstract = {The aim of this project was to investigate the P53 gene mutations in exon 8 in the patients with astrocytoma type brain tumor. This was an in vitro study, in which the extraction of DNA from 30 samples of brain tissue was performed by phenol-chloroform protocols. After polymerase chain reaction (PCR) amplification of exon 8 of p53 genes, screening by single strand conformation polymorphism (SSCP) was performed to detect the shift. In this study, three malignant novel missense mutations in one sample with grade 4 of astrocytoma were detected. Also one synonymous mutation in grade 4 of astrocytoma was detected. The findings were indicated that mutations in exon 8 of the P53 gene mostly were in malignant astrocytoma brain tumor type, which is important in diagnosis and gene therapy of brain tumors.}, keywords = {astrocytoma,p53,exon 8,Mutation}, url = {https://www.healthbiotechpharm.org/article_133503.html}, eprint = {https://www.healthbiotechpharm.org/article_133503_ca2e7cbb703f415e70682e1f924a7190.pdf} } @article { author = {}, title = {Analytical assay and morphological study of fungal cells treated with coumarin derivatives}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {2}, number = {1}, pages = {46-61}, year = {2018}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2018.14}, abstract = {In this research, synthesized coumarin derivatives were evaluated as antifungal drugs. Scanning electron microscopy (SEM) and transmittance electron microscopy (TEM) techniques were used to investigate morphological changes of fungal cells. In the cells treated with subinhibitory concentrations of compound 61, cell wall was rugged. However, the compound 23 and AmB groups had very few cells with a wrinkled surface. TEM results showed changes in vacuoles of the cells treated with coumarins. Our findings suggest that this increase is due to the phosphodiesterase (PD) inhibitory activity of coumarins.}, keywords = {Fungal cells,morphological study,coumarin derivatives}, url = {https://www.healthbiotechpharm.org/article_133505.html}, eprint = {https://www.healthbiotechpharm.org/article_133505_4522f52b81b987729cad561effc9047e.pdf} }