@article { author = {}, title = {Pathogenesis, significant biomarkers and treatment strategies in ovarian cancer}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {4}, number = {2}, pages = {1-27}, year = {2020}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2020.07}, abstract = {The aim of this paper is to study the pathogenesis, significant biomarkers and treatment strategies in ovarian cancer. Because of poor prognosis, ovarian cancer is usually diagnosed in final stages and although the first phase of treatment and chemotherapy usually seems to be a nice therapeutic approach but after a while, in many cases the disease will return. There are several biomarkers in order to diagnose the ovarian cancer but nowadays the combination of CA125 and HE4 are used and Pelvic examinations and diagnostic sonographies can also help early detection. Some factors such as using contraception pills, breastfeeding, early menopause and proper nutrition can decrease the risk of being involved with this malignancy, but instead late menopause, due to increasing the number of ovulation cycle, and also smoking tobacco can increase the risk of this disease. Several medicines are used to improve the inhibition of angiogenesis chemotherapy such as: bevacizumab and cediranib.}, keywords = {ovarian cancer,Biomarkers,risk factors,Targeted therapies}, url = {https://www.healthbiotechpharm.org/article_133115.html}, eprint = {https://www.healthbiotechpharm.org/article_133115_ecba786d4a0d9cb89fc84767c97008af.pdf} } @article { author = {}, title = {Novel coronavirus disease-19: An overviwe of pathogenesis, health influences and measures}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {4}, number = {2}, pages = {28-36}, year = {2020}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2020.08}, abstract = {The coronavirus disease-19 (COVID-19) signs mostly include fever and respiratory symptoms (unusual viral pneumonia by SARS-Coronaviruses 2 or SARS-CoV-2). The Receptor-Binding Domain (RBD) of COVID-19 and SARS-CoV are similar, causing cross-reactivity of anti-SARS-CoV antibodies with associated spike protein, exerting promising implications for rapid development of vaccines and therapeutic antibodies against COVID-19. ACE2 is the SARS TMPRSS2 for spike (S) protein receptor for initiation of infection; hence, it is a target for pharmacological intervention. Furthermore, designing novel monoclonal antibodies binding specifically to COVID-19 RBD is essential. A viral S proteins (TMPRSS2) was proposed for clinical use by blocking the viral intake by cell.}, keywords = {Corona virus disease-19,virulence,Prevention,Control}, url = {https://www.healthbiotechpharm.org/article_133117.html}, eprint = {https://www.healthbiotechpharm.org/article_133117_8fd51b49bb4d3ed71046102b02b3b927.pdf} } @article { author = {}, title = {Formulation and evaluation of mucoadhesive microballons of nizatidine for peptic ulcer}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {4}, number = {2}, pages = {37-56}, year = {2020}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2020.09}, abstract = {The mucoadhesive microballons were prepared by using combination of polymer-polymer complexation (PAA-PVP) using solvent diffusion method. Mucoadhesive microballons is one of dosage forms which make available the prospectto increase the bioavailability of drug. The prepared delivery system managing the discharge rate of nizatidine between therapeutic absorption by extended the gastric emptying time. The delivery systems make certain accessibility of drug content at the assimilation site for the preferred period of time, also the possibility of enhancing the bioavailability and control the release of nizatidine show evidence of absorption by prolonging the gastric emptying time of the dosage form.}, keywords = {peptic ulcer,mucoadhesive microballons,nizatidine}, url = {https://www.healthbiotechpharm.org/article_133118.html}, eprint = {https://www.healthbiotechpharm.org/article_133118_46b97a54be6572799646ca780c703dc3.pdf} } @article { author = {}, title = {Simple and fast identification of atropine and atropine-like molecules in some medicinal plant extracts by molecularly imprinted polymers}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {4}, number = {2}, pages = {57-69}, year = {2020}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2020.10}, abstract = {In this study, the extracts of four plants with alkaloid and one plant without alkaloid were used. Datura innoxia Miller, Withania somnifera (L.) Dunal, Physalis alkekengi, Lactuca serriola L. Plants with alkaloids and Salvia sclarea L. without alkaloids that were collected from Tehran and other plants were collected from Firouz-Abad in Fars Province in 2019. The lowest concentration of atropine, which was detected in interaction with molecularly imprinted polymers (MIP), was 0.1 μg/𝑚𝑙 and it was raised with increasing observed fluorescent light concentration. Also atropine-molecularly imprinted polymers (atropine-MIP) with concentrations of 10 μg/𝑚𝑙 and 100 μg/𝑚𝑙 of tropic acid and tropine, which are atropine-like substances, produced fluorescent radiation.}, keywords = {Atropine,alkaloid,molecularly imprinted polymer (MIP)}, url = {https://www.healthbiotechpharm.org/article_133119.html}, eprint = {https://www.healthbiotechpharm.org/article_133119_b528a7eb0bf5fd608105d6d287434825.pdf} } @article { author = {}, title = {Siger rice made from cassava (waxy) as rice which is recommended for diabetics}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {4}, number = {2}, pages = {70-79}, year = {2020}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2020.11}, abstract = {Siger rice has a very high amylose. The high amylose in Siger rice caused the amylose came out from the starch granules during the cooking process and release the water when it was cold until the rice became hard. This research aimed to measure the content of Siger rice from sticky cassava, using a single short screw extruder. The research results showed that the addition of water had significant effect on texture, color, taste, flavour of Siger rice. Addition of 30 % water produced the best sensory properties with texture score of 2.79 (same like white rice), color is 3.27 (slightly yellowish-white), taste and flavour is 3.35 (rather-like). This Siger rice contained water content 9.81 %, ash 0.47 %, protein 2.13 %, fat 0.90 %, crude fiber 4.79 %, carbohydrate 81.90 %, glycemic index 29, and HCN 17 mg/kg. The results show that the content of Siger rice was acceptable, safe and very good for diabetics.}, keywords = {Cassava,diabetic,Siger rice,Amylose}, url = {https://www.healthbiotechpharm.org/article_133120.html}, eprint = {https://www.healthbiotechpharm.org/article_133120_cb6b9b0fe4103314b5838ff09b896607.pdf} } @article { author = {}, title = {Current scenario of nutraceuticals and food fortification in India}, journal = {Health Biotechnology and Biopharma (HBB)}, volume = {4}, number = {2}, pages = {80-89}, year = {2020}, publisher = {Health Biotechnology and Biopharma}, issn = {2538-4414}, eissn = {2538-4414}, doi = {10.22034/HBB.2020.12}, abstract = {As nowadays the consumption of functional food providing essential nutrients for boosting the immunity should be correlated with scientific evidence providing standards that can be correlated for the community worldwide. Food fortification is a process which helps to improve public health and enhance the immunity of the population overall. As we all know that the phenolic compounds act as antioxidants, so processing byproducts from plant sources particularly rich in number of essential elements can be used as value-added ingredients for application in food supplements for overcoming the health problems worldwide. The purpose of this review is to identify and study the importance of food fortification and importance of nutraceuticals for their efficacy and effectiveness in India and over the world for improving the health.}, keywords = {Fortification,Nutraceuticals,functional foods,public health,Dietary supplements}, url = {https://www.healthbiotechpharm.org/article_133121.html}, eprint = {https://www.healthbiotechpharm.org/article_133121_850934afc7f6846eb15a3cb0cdffa590.pdf} }