New insights into the effects of hydroxychloroquine in COVID-19
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article
2021
eng
In late 2019 until 2021, the novel coronavirus disease (COVID-19) has become pandemic. This disease is related to severe inflammatory symptoms of the respiratory epithelial cells and the dysfunction of several organs. One of the suggested drugs to reduce the inflammation caused by COVID-19 is hydroxychloroquine. Studies have shown this drug blocks the inflammatory pathway of nuclear factor-κB by blocking P21 activated kinase 1. Also, nanoparticle vaccines Poly Lactide-Glycolide) Acid (PLGA) containing hydroxychloroquine are effective in cancer by stimulating CD8T + cells responses. This study assumed that hydroxychloroquine was effective in inhibiting COVID-19 with these mechanisms.
Health Biotechnology and Biopharma (HBB)
Health Biotechnology and Biopharma
2538-4414
5
v.
2
no.
2021
1
6
https://www.healthbiotechpharm.org/article_138021_bdedc0af9095b30f181f3b31379c3fbc.pdf
dx.doi.org/10.22034/HBB.2021.13
The frequency of hepatitis C virus genotypes with chronic hepatitis C referred to Nikopour clinic in Yazd
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article
2021
eng
The aim of this study was to investigate the frequency of hepatitis C virus genotypes with chronic hepatitis C referred to Nikopour clinic of Yazd during 2010-2020. In this cross-sectional study RT-PCR was used to determine the genotype of hepatitis C virus. The patient information was recorded in a questionnaire and finally the data were analyzed by SPSS software. During this study, 104 patients with hepatitis C were evaluated with a mean age of 42.9 years. The most common hepatitis C virus genotypes were 3a, 1a and 3, respectively. The HCV genotype was significantly associated with risk factor and history of blood transfusion in patients. Considering that the predominant genotype is 3a and about 35.6 %, seems that genotype determination would be a candidate for treatment.
Health Biotechnology and Biopharma (HBB)
Health Biotechnology and Biopharma
2538-4414
5
v.
2
no.
2021
7
13
https://www.healthbiotechpharm.org/article_138084_f0bdbcd44d81e7a1d7301b89dc8ebd7a.pdf
dx.doi.org/10.22034/HBB.2021.14
The IFIH1 gene polymorphism (Ala946Thr) association with the type 2 diabetes mellitus and hypertension among Iraqi patients
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article
2021
eng
Numerous genes with Single Nucleotide Polymorphisms (SNPs) are implicated in the Type 2 Diabetes Mellitus (T2DM) development. This work conducted as a case-control to assess the association of IFIH1 gene polymorphism (Ala946Thr) to the T2DM and hypertension among Iraqi patients. A total of 100 T2DM patients were enrolled, 50 of them had hypertension. Moreover, 100 subjects were healthy that used as control group. All participants were genotyped using Real Time Polymerase Chain Reaction (RT-PCR). The G allele was more frequent in T2DM+ Hypertension (HTN) and T2DM without HTN (0.51 % and 0.52 %, respectively), while were less frequent (0.425 %) in the control group. The AA genotype was a significant risk factor for T2DM -HTN development. The GA genotype was also significantly (p <0.01 and OR: 5.8-8.3 associated, while the combination of the genotypes GA and AA depicted a significant P value<0.03 and OR of 4.42. The GA genotype was significantly related to the T2DM without hypertension.
Health Biotechnology and Biopharma (HBB)
Health Biotechnology and Biopharma
2538-4414
5
v.
2
no.
2021
14
25
https://www.healthbiotechpharm.org/article_138090_3805ac5a17b8e19d12fb4ee5dde6a29b.pdf
dx.doi.org/10.22034/HBB.2021.15
The rate of smoking and drug addiction among patients with COVID-19 specially based on sex genetic factor
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article
2021
eng
The aim of this study was to determine the extent of tobacco and drug addiction to opium, methamphetamine and heroin in hospitalized patients due to COVID-19. In this cross-sectional descriptive study, the rate of smoking and drug addiction among COVID-19 patients admitted to Shahid Sadoughi hospital in Yazd was investigated. A total of 500 patients were studied and patient information such as smoking and drug use history, dosage, type of substance, length of hospital stay and severity of the disease were extracted in this paper. Then the data were entered into SPSS software and analyzed. No significant relationship was found between patients sex (Main genetic factor) and smoking with disease severity. Also, no significant relationship was found between smoking and length of hospital stay. Also, there was no significant difference between the severity of clinical symptoms in drug users and other subjects. In this study, the prevalence of smoking among COVID-19 patients was about 6.6 %.
Health Biotechnology and Biopharma (HBB)
Health Biotechnology and Biopharma
2538-4414
5
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2
no.
2021
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33
https://www.healthbiotechpharm.org/article_138091_85197a5bbb32168b05283336f9b4c2a7.pdf
dx.doi.org/10.22034/HBB.2021.16
Impact of mass media on the population as a precautionary prevention from COVID-19 in Iraq
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article
2021
eng
The aim of this study was to identify the impact of both traditional mass media and social digital media on the population to prevent the Corona virus disease-19 (COVID-19). Three hundred twenty participants were included. A questionnaire was prepared consisting of socio-demographic characteristics and the effect of traditional mass media and mobile digital media on the population. The sources used for information included TV (72.8 %), Facebook (71.2 %), health professionals (64.4 %), Instagram (28.1 %), Twitter (16.8 %), Radio (14.4 %) and mobile Apps (Viber and WhatsApp being 30.9 %). Social Media could be blamed for aiding the spread of stress and hysteria among people.
Health Biotechnology and Biopharma (HBB)
Health Biotechnology and Biopharma
2538-4414
5
v.
2
no.
2021
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45
https://www.healthbiotechpharm.org/article_138092_b38531a56b2ed3a9e4d40fbeaa1ebdbe.pdf
dx.doi.org/10.22034/HBB.2021.17
Association of non-synonymous +326 A>T and synonymous +258 G>A polymorphisms of omentin-1 gene (ITLN-1) among type 2 diabetes patients of Pakistan
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article
2021
eng
Omentin is an adipocytokine that has anti-diabetic property. Genetic variations in ITLN-1 may affect blood glucose level by inactivating Akt/PKB signaling pathway. The aim of this study was to evaluate the association between ITLN-1 gene non-synonymous +326 A>T and synonymous +258 G>A polymorphisms with susceptibility to T2DM. Significant distribution observed in genotype frequency of +258G>A variants in T2DM patients and controls. Genetic models for co-dominant, dominant and recessive genotypes for +326 A>T and recessive genotype for +258 G>A were found capable of increasing the risk of T2DM. Allelic association analysis showed T-allele (+326 A>T) conferred higher risk of the diabetes. Results suggested that genetic variants of ITLN-1 may act as possible molecular targets for early diagnosis of T2DM in future.
Health Biotechnology and Biopharma (HBB)
Health Biotechnology and Biopharma
2538-4414
5
v.
2
no.
2021
46
60
https://www.healthbiotechpharm.org/article_138093_068fae20bdeae75c604e3d75631943c9.pdf
dx.doi.org/10.22034/HBB.2021.18