Helsy Junaidi; Jeanne Adiwinata Pawitan
Abstract
The development of tissue engineering provides various opportunities to vascular tissue engineering. Scaffold plays an essential role in vascular tissue engineering. The selection of biomaterials used as scaffolds will determine the success of vascular tissue engineering. The structure of vascular system, ...
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The development of tissue engineering provides various opportunities to vascular tissue engineering. Scaffold plays an essential role in vascular tissue engineering. The selection of biomaterials used as scaffolds will determine the success of vascular tissue engineering. The structure of vascular system, which consists of three layers, is embedded in extracellular matrices that provide the mechanical properties of the system. Therefore, tissue engineering of a vascular structure needs various suitable biomaterials as scaffold that can support vascular system mechanical properties and function. Various materials were used for 3D printing and electro-spinning with good results, including collagen, gelatin, and alginate. Varying sizes of blood vessels require scaffolds with biomaterials that could adapt to their shape, size and approximate the mechanical properties of the blood vessels.
Abstract
Platelets are thought to aid in hemostasis, thrombosis, inflammation, wound healing, and immunity. R4 is a novel thiazole derivative that may decrease angina and ischemia. An aggregometer evaluated R4 impact on PRP. Spectrophotometric method measured anti-lipoxygenase activity of R4. In its absence, ...
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Platelets are thought to aid in hemostasis, thrombosis, inflammation, wound healing, and immunity. R4 is a novel thiazole derivative that may decrease angina and ischemia. An aggregometer evaluated R4 impact on PRP. Spectrophotometric method measured anti-lipoxygenase activity of R4. In its absence, the platelet aggregation in PRP showed 88 % and 75 % with collagen and ADP, respectively, while R4 inhibited 100 % collagen-induced platelet aggregation at 1.1875 μM and ADP-induced platelet aggregation up to 100 % at 0.9375 μM. Collagen and ADP induced R4 antiplatelet IC50 values were 0.55 ± 0.12 μM, and 0.26 ± 0.20 μM, respectively. R4 inhibited lipoxygenase significantly with an IC50 of 26.65 ± 0.16 μM. The novel compound, R4, may also assist platelet-associated thromboembolic disorders.
