Mohadeseh Nemati; Fahima Danesh Pouya; Fateme Zarein; Mahdieh Nemati; Yousef Rasmi; Jafar Rezaie; Tooba Hallaj
Abstract
Cancer cells are metabolically different from normal cells, including the Warburg effect and uses glutamine to fill the Tricarboxylic Acid (TCA) cycle. It was demonstrated inhibiting glutamine metabolism prevents tumor growth. The mammalian Target of Rapamycin (mTOR) is one of the signaling pathways ...
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Cancer cells are metabolically different from normal cells, including the Warburg effect and uses glutamine to fill the Tricarboxylic Acid (TCA) cycle. It was demonstrated inhibiting glutamine metabolism prevents tumor growth. The mammalian Target of Rapamycin (mTOR) is one of the signaling pathways that involve glutamine metabolism in cancer. Carbon Quantum dots (CQ-dots) nanoparticles are associated with the mTOR signaling pathway. These findings indicate that irregular glutamine metabolism are related to the growth of Colorectal Cancer (CRC). Thus, the activating glutamine metabolism via the mTOR pathway in CQ-dots treatments has toxic effect on CRC therapy. So, more investigations need for therapeutic application of these nanocarriers.
Biological sciences
Mohammad Ali Pahlevan Neshan; Payam Shahnazi Gerdehsang; Ahmad Bereimipour; Nazila Bostanshirin; Haniyeh Sadat Hosseininia; Kaykhosro Moridi; Amin Ebrahimi Sadrabadi; Arsalan Jalili
Abstract
Chronic inflammation in colorectal cancer can result in the progression of tumorigenesis. Inflammation in the colorectal part of the body can be affected by microbiota, as well as an individual diet. These two factors play a critical role in cancer types related to the colon and rectum. This inflammation ...
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Chronic inflammation in colorectal cancer can result in the progression of tumorigenesis. Inflammation in the colorectal part of the body can be affected by microbiota, as well as an individual diet. These two factors play a critical role in cancer types related to the colon and rectum. This inflammation could lose the protective epithelial layer of colorectal cancerous cells and, thus, translocation of healthy flora to inner layers. Pathogenic bacteria can also cause inflammation induction and tumorigenesis in the intestines. A change in the bacteria composition and some bacteria metabolites can also play a role in colorectal cancer. Dysbiosis can be affected by an individual diet. In this paper, the importance of diet and microbiota content on inflammation has been reviewed, and finally, in silico investigation confirmed their interplay.
