Biological sciences
Mehdi Ahmadifar; Reihaneh Balali; sadaf reihani; zeinab jarban
Abstract
In recent studies, the focus on zebrafish, as a suitable laboratory model for studying vertebrate gene function, has increased dramatically. We evaluated the similarity between the three genes KLF2, MSX1 and SOX9 in humans and zebrafish. The KLF2 gene plays a role in heart and immunity of humans and ...
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In recent studies, the focus on zebrafish, as a suitable laboratory model for studying vertebrate gene function, has increased dramatically. We evaluated the similarity between the three genes KLF2, MSX1 and SOX9 in humans and zebrafish. The KLF2 gene plays a role in heart and immunity of humans and zebrafish. In zebrafish, KLF2 gene is involved in immunogenesis and angiogenesis. This gene can increase the expression of thrombomodulin and endothelial nitric oxide synthase for human angiogenesis and vascular volume modulation. Zebrafish and human MSX genes are involved in the development of the ethmoid plate and are expressed in the neural crest and pre-placodal ectoderm. In zebrafish and humans, members of the SOX family play an important role in embryogenesis and sex determination. Therefore, understanding the relationship between zebrafish and human genes is important for effective modeling of human genetic diseases.
Biological sciences
Mehdi Ahmadifar; Mina Nikandish; Nika Mashhadizadeh; Mohammad Hossein Azhir; sadaf reihani; ghazal hakiminezhad
Abstract
Polycystic Ovary Syndrome (PCOS) is the most common heterogeneous Endocrine (EC) disorder in women of childbearing age, which has an increasing trend in the number of patients recently. Although women with PCOS have been shown to triple the risk of EC compared to women without polycystic ovary syndrome, ...
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Polycystic Ovary Syndrome (PCOS) is the most common heterogeneous Endocrine (EC) disorder in women of childbearing age, which has an increasing trend in the number of patients recently. Although women with PCOS have been shown to triple the risk of EC compared to women without polycystic ovary syndrome, there are precise molecular mechanisms that increase the risk of EC in women with ovarian syndrome. Therefore, clinical strategies to prevent EC in PCOS are not well known. Although, elevated estrogen levels and decreased apoptosis have been suggested as potential mechanisms, there is no clarity on how these and other factors interact to increase the risk of EC in polycystic ovary syndrome. In this article, we try to review the functional mechanisms of TUBB8, SOX9 and BCL2 genes to examine their effect on controlling or promoting the risk of EC.