TarakaRamarao Ch; Ravali Jami
Abstract
Ezetimibe is an antihyperlipidemic drug that lowers cholesterol levels. The purpose of this study was to compare different amounts of solid dispersions and formulations using various carriers in order to improve the dissolution. The Design Expert software was used to perform Analysis of Variance (ANOVA), ...
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Ezetimibe is an antihyperlipidemic drug that lowers cholesterol levels. The purpose of this study was to compare different amounts of solid dispersions and formulations using various carriers in order to improve the dissolution. The Design Expert software was used to perform Analysis of Variance (ANOVA), 3D surface plots, counter plots, optimization, and desirability for a two-level factorial. Sun pharma laboratories limited market product, Ezentia, was compared to the optimised formulation, F6. We compared amount of released that was considerably increased using the solid dispersion method. The dissolving characteristics of the improved formulation, F6, and the market tablet were found to be similar, with f1 and f2 values of 11.71 and 99.89. When the experimental data matched the expected values, the model predictability and validity were shown.
Abstract
Biopharmaceuticals are drugs or vaccines, developed via biotechnology process. Biopharming is production of pharmaceuticals in live organisms. Different platforms can be used for biopharmaceuticals production. Prokaryotes, yeast, fungi, insect cells, mammalian cells, transgenic plants, and transgenic ...
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Biopharmaceuticals are drugs or vaccines, developed via biotechnology process. Biopharming is production of pharmaceuticals in live organisms. Different platforms can be used for biopharmaceuticals production. Prokaryotes, yeast, fungi, insect cells, mammalian cells, transgenic plants, and transgenic animals can be used for production of recombinant proteins.Genentech, the first biotech company, gained FDA approval for recombinant human insulin in 1982. Nowadays, more than 200 approved biopharmaceuticals have been brought to market. The world's top pharmaceutical companies are producing biopharmaceuticals in their own factories. In Iran, there are twenty-three biopharmaceutical companies that produce about twenty-five biopharmaceutical products. Most of them formulate their products using active ingredients of other countries. Pooyesh darou, Cinnagen, Pasteur institute of Iran, Aryogen biopharma, and Aryatinagen produce active ingredients of drugs, and formulate biopharmaceuticals. Iranian biopharma companies will be able to produce more and better biopharmaceuticals in near future.