Biological sciences
Sanaz Kavoosi; Sanam Rezazadeh Chafjiri; Nastaran Asghari Moghaddam
Abstract
The gene Enhancer of Zeste Homolog 2 (EZH2) is shown to be involved in the progression of the angiogenesis in cancer including prostate cancer, also it is a well-known enzyme catalytic subunit, initially acting as a histone methyltransferase, to prevent expressing gene by trimethylating lysine at the ...
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The gene Enhancer of Zeste Homolog 2 (EZH2) is shown to be involved in the progression of the angiogenesis in cancer including prostate cancer, also it is a well-known enzyme catalytic subunit, initially acting as a histone methyltransferase, to prevent expressing gene by trimethylating lysine at the histone H3 position. According to previous studies, it is obvious that in some cancer, such as prostate cancer, EZH2 is overexpressed. In this review, the regulation and function of the EZH2 gene and also signaling pathways that are regulated by this gene in angiogenesis process were reviewed. In addition, EZH2 has been playing an important role as a target in clinical trials to provide small inhibitor molecule that classified into two groups including new chemotherapy agents and repositioning drugs with the aim of cancer therapy and malignancy.
Abstract
It is observed that some venom may have an anticancer effect. Hemiscorpius lepturus is a most dangerous scorpion in Iran. Heminecrolysin is the most toxic fraction of Hemiscorpius lepturus venom and it is responsible for hemolytic effects of the venom. In this research, we purified heminecrolysin by ...
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It is observed that some venom may have an anticancer effect. Hemiscorpius lepturus is a most dangerous scorpion in Iran. Heminecrolysin is the most toxic fraction of Hemiscorpius lepturus venom and it is responsible for hemolytic effects of the venom. In this research, we purified heminecrolysin by FPLC, and HPLC methods and used MTT assay in prostatic cancer cell line (PC-3 cells). We observed that H.lepturus venom and its fraction (heminecrolysin) had anticancer effects on prostatic cancer cell line (PC-3) and inhibited cell growth.
