TarakaRamarao Ch; Ravali Jami
Abstract
Ezetimibe is an antihyperlipidemic drug that lowers cholesterol levels. The purpose of this study was to compare different amounts of solid dispersions and formulations using various carriers in order to improve the dissolution. The Design Expert software was used to perform Analysis of Variance (ANOVA), ...
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Ezetimibe is an antihyperlipidemic drug that lowers cholesterol levels. The purpose of this study was to compare different amounts of solid dispersions and formulations using various carriers in order to improve the dissolution. The Design Expert software was used to perform Analysis of Variance (ANOVA), 3D surface plots, counter plots, optimization, and desirability for a two-level factorial. Sun pharma laboratories limited market product, Ezentia, was compared to the optimised formulation, F6. We compared amount of released that was considerably increased using the solid dispersion method. The dissolving characteristics of the improved formulation, F6, and the market tablet were found to be similar, with f1 and f2 values of 11.71 and 99.89. When the experimental data matched the expected values, the model predictability and validity were shown.
