Biological sciences
Mehdi Ahmadifar; Reihaneh Balali; sadaf reihani; zeinab jarban
Abstract
In recent studies, the focus on zebrafish, as a suitable laboratory model for studying vertebrate gene function, has increased dramatically. We evaluated the similarity between the three genes KLF2, MSX1 and SOX9 in humans and zebrafish. The KLF2 gene plays a role in heart and immunity of humans and ...
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In recent studies, the focus on zebrafish, as a suitable laboratory model for studying vertebrate gene function, has increased dramatically. We evaluated the similarity between the three genes KLF2, MSX1 and SOX9 in humans and zebrafish. The KLF2 gene plays a role in heart and immunity of humans and zebrafish. In zebrafish, KLF2 gene is involved in immunogenesis and angiogenesis. This gene can increase the expression of thrombomodulin and endothelial nitric oxide synthase for human angiogenesis and vascular volume modulation. Zebrafish and human MSX genes are involved in the development of the ethmoid plate and are expressed in the neural crest and pre-placodal ectoderm. In zebrafish and humans, members of the SOX family play an important role in embryogenesis and sex determination. Therefore, understanding the relationship between zebrafish and human genes is important for effective modeling of human genetic diseases.
Medicinal sciences
Nastaran Sahraei; Mina Mobin Rahni; Mehdi Ahmadifar
Abstract
Leukemia as one of the common cancers is still studied and needs improvement in diagnosis and treatment. In this study, we examined the activity of hematopoietic stem cells, which can be a precursor to leukemia. Hematopoietic cancer cells, by affecting the bone marrow, preserve the source of stem cells ...
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Leukemia as one of the common cancers is still studied and needs improvement in diagnosis and treatment. In this study, we examined the activity of hematopoietic stem cells, which can be a precursor to leukemia. Hematopoietic cancer cells, by affecting the bone marrow, preserve the source of stem cells for the development of blood cancers. Also, in this study, various signaling pathways, including Wnt, which regulates the production of blood cells, and the abnormal expression and function of miRNAs in leukemia were investigated. We also analyzed various cellular and molecular factors that play a role in the occurrence of leukemia, as well as further studies in the field of cancer and immunology, which can lead to the discovery of new treatments and improve the function of the body's immune system against cancer cells.
Biological sciences
Tina mandegarfard; Zahra Arabi; Mahsa Nejati; Nika Mashhadizadeh; Mina Nikandish; Mehdi Ahmadifar
Abstract
Resumption of nuclear maturation and cytoplasmic changes occur during in vitro maturation. In vitro maturation of the egg provides a stage called Metaphase II (MII) that is required for in vitro fertilization. This study aimed to investigate the effect of replacing Follicle-Stimulating Hormone (FSH) ...
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Resumption of nuclear maturation and cytoplasmic changes occur during in vitro maturation. In vitro maturation of the egg provides a stage called Metaphase II (MII) that is required for in vitro fertilization. This study aimed to investigate the effect of replacing Follicle-Stimulating Hormone (FSH) with plant extract that 5 groups were used. The null group, which consisted only of oocytes, the control group, which used Fetal Bovine Serum (FBS) and FSH, the 3 experimental groups, in which different doses of Ajuga L. extract were substituted for FSH. Ajuga extract with appropriate dose increased the prevalence of Germinal Vesicle Degradation (GVBD), growth rate and maturity of immature mouse oocytes to MII stage.
Biological sciences
Mehdi Ahmadifar; Mina Nikandish; Nika Mashhadizadeh; Mohammad Hossein Azhir; sadaf reihani; ghazal hakiminezhad
Abstract
Polycystic Ovary Syndrome (PCOS) is the most common heterogeneous Endocrine (EC) disorder in women of childbearing age, which has an increasing trend in the number of patients recently. Although women with PCOS have been shown to triple the risk of EC compared to women without polycystic ovary syndrome, ...
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Polycystic Ovary Syndrome (PCOS) is the most common heterogeneous Endocrine (EC) disorder in women of childbearing age, which has an increasing trend in the number of patients recently. Although women with PCOS have been shown to triple the risk of EC compared to women without polycystic ovary syndrome, there are precise molecular mechanisms that increase the risk of EC in women with ovarian syndrome. Therefore, clinical strategies to prevent EC in PCOS are not well known. Although, elevated estrogen levels and decreased apoptosis have been suggested as potential mechanisms, there is no clarity on how these and other factors interact to increase the risk of EC in polycystic ovary syndrome. In this article, we try to review the functional mechanisms of TUBB8, SOX9 and BCL2 genes to examine their effect on controlling or promoting the risk of EC.
