Seyyed Mohammad Shahcheragh; Azizollah Habibi; Masoomeh Shirzad; Yekta Farahani; Soroush Sardari
Abstract
In the present study, a one-pot, green and three-component route for synthesis of Thiocarbohydrazone (TCS) derivatives is described. This reaction was performed in choline chloride/urea (1:2) as Deep Eutectic Solvent (DES). The structures were characterized by FTIR, 1H NMR, 13C NMR spectra and elemental ...
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In the present study, a one-pot, green and three-component route for synthesis of Thiocarbohydrazone (TCS) derivatives is described. This reaction was performed in choline chloride/urea (1:2) as Deep Eutectic Solvent (DES). The structures were characterized by FTIR, 1H NMR, 13C NMR spectra and elemental analysis. The derivatives were evaluated for their anti-mycobacterial activity against Mycobacterium bovis BCG, and the results revealed that among the synthesized compounds (1a-1h, 2a-2h, 3a-3h), 3b, 3c and 1b exhibited the highest activity with MIC value of 7.81 and 11.71 μg/mL. Additionally, the target compounds were evaluated for their anti-microbial activity against E.coli and Candida Albicans and the result indicated that in contrast to the low antifungal activity, the produced derivatives with electron-withdrawing substitution at the ortho, meta and para positions of benzyl ring includes 1d, 2b and 3d-3g demonstrated remarkable anti-micobacterial activities.
Biological sciences
Seyedeh Mahsa Hosseini; Raheem Haddad; Soroush Sardari
Abstract
It has been found that natural microorganism have a siginificant role in the production and development of new medicines. The present study aimed to evaluat biotransformation of atropine, 4-hydroxy coumarin, 8-hydroxy quinoline, indole and industrially compound (penicillin G), arrive in the human body, ...
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It has been found that natural microorganism have a siginificant role in the production and development of new medicines. The present study aimed to evaluat biotransformation of atropine, 4-hydroxy coumarin, 8-hydroxy quinoline, indole and industrially compound (penicillin G), arrive in the human body, by some natural microorganism (Escherichia coli ATCC 25922, Bacillus subtilis ATCC 6051, Lactobacillus acidophilus ATCC 314, Mycobacterium Bovis (BCG), Saccharomyces cerevisiae ATCC 5052, and Candida albicans ATCC 10231), for the first time. The best values for the concentration and required times were evaluated for each metabolites in microbioal biotransformation process. The progress of the formation of the metabolites were monitored by Thin Layer Chromatography (TLC) method. Obtained results showed that only indole, atropine, and 4-hydroxy coumarin could be biotransformed by Candida albicans ATCC 10231, Escherichia coli ATCC 25922, and Saccharomyces cerevisiae ATCC 5052, respectively.
