Medicinal sciences
Ria Andreinie; Jeanne Adiwinata Adiwinata Pawitan
Abstract
Treatment of cartilage damage is not satisfactory mainly due to cartilage nature that is avascular, so that its nutrition only depends on the diffusion process, which does not support regeneration. One of the new approaches for regeneration of injured cartilage that have a future is tissue engineering. ...
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Treatment of cartilage damage is not satisfactory mainly due to cartilage nature that is avascular, so that its nutrition only depends on the diffusion process, which does not support regeneration. One of the new approaches for regeneration of injured cartilage that have a future is tissue engineering. There have been many clinical applications of tissue engineering in knee cartilage defects with varying results that it is not known, which method provides the best result. Therefore, this review highlighted the clinical applications of various tissue engineering methods in knee cartilage defects and did comparison of the various procedures. Our result showed that the best healing results was tissue engineering using GelrinC, and the method that had the lowest side effects was tissue engineering using hydrogel-based autologous chondrocyte transplantation.
Helsy Junaidi; Jeanne Adiwinata Pawitan
Abstract
The development of tissue engineering provides various opportunities to vascular tissue engineering. Scaffold plays an essential role in vascular tissue engineering. The selection of biomaterials used as scaffolds will determine the success of vascular tissue engineering. The structure of vascular system, ...
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The development of tissue engineering provides various opportunities to vascular tissue engineering. Scaffold plays an essential role in vascular tissue engineering. The selection of biomaterials used as scaffolds will determine the success of vascular tissue engineering. The structure of vascular system, which consists of three layers, is embedded in extracellular matrices that provide the mechanical properties of the system. Therefore, tissue engineering of a vascular structure needs various suitable biomaterials as scaffold that can support vascular system mechanical properties and function. Various materials were used for 3D printing and electro-spinning with good results, including collagen, gelatin, and alginate. Varying sizes of blood vessels require scaffolds with biomaterials that could adapt to their shape, size and approximate the mechanical properties of the blood vessels.
Medicinal sciences
Jeanne Adiwinata Pawitan; Corry Novita Mahama
Abstract
Traumatic Brain Injury (TBI) can occur when the head suddenly hits an object and the internal forces produce damage to the brain, disrupting its normal function, with or without structural changes. TBI causes disability and death to almost all age groups. This review aimed to describe the biomechanics ...
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Traumatic Brain Injury (TBI) can occur when the head suddenly hits an object and the internal forces produce damage to the brain, disrupting its normal function, with or without structural changes. TBI causes disability and death to almost all age groups. This review aimed to describe the biomechanics that were involved in brain injury of varying severity degrees and summarizes the neurochemical and metabolic changes to predict the effect of brain injury. There are various methods in biomechanics measurements for TBI, as well as computational models to understand several pathophysiology and effects of TBI that are very important to find better TBI treatments. Moreover, several neurochemical and metabolic changes in brain may explain the short and long-term effect of TBI to the brain. The various methods in biomechanics measurements for TBI are very important to find better treatments.
