Document Type : Original Research Article
Authors
- Elaheh Gholami Roudmajan 1
- Ali H. Al-Marzoqi 2
- Miaad K. Alkhudhairy 3
- Maryam Kohansal 4
- Abdolmajid Ghasemian 5
- Seyed Masoud Houshmand 6
1 1- National Institute for Genetic Engineering and Biotechnology, Iran
2 University of Babylon, Iraq
3 College of Health and Medical Techniques, Al-Furat Al-Awsat Technical University, Kufa, Iraq
4 pnu
5 3- Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
6 1- National Institute for Genetic Engineering and Biotechnology
Abstract
A leading risk factor for cervical cancer (CC) initiation and progress includes human papillomavirus (HPV) infection. The telomerase catalytic subunit which regulates senescence and proliferation (carcinogenesis) is encoded by human telomerase reverse transcriptase (hTERT) gene. Our objective was the assessment of high risk HPV genotypes (16, 18 and 31) association with two polymorphisms of hTERT gene (rs2736098 and rs2736100) in CC development. Forty CC specimens were retired and 49 blood samples from healthy individuals were used as control group. The PCR-RFLP was performed for the detection of rs2736098 and rs2736100 polymorphisms. The differences of A, C or G alleles were not significant between case and control. Accordingly, among 10 high risk HPV genotypes, genotype 18 was detected and there was no meaningful relation between neither the hTERT rs2736098 nor the rs2736100 polymorphisms and CC risk.
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