Document Type : Original Research Article

Authors

• Noor Adnan Najm ¹
• Ekhlas Sabah Hassan ²

¹ Department of Pharmacology & Therapeutics, Faculty of Medicine, University of Kufa, Najaf, Iraq.

² Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa, Najaf, Iraq.

Abstract

Sepsis is now more commonly regarded as an uncontrolled inflammatory and immune response throughout the body, triggered by microbial invasion and resulting in high mortality rate from organ damage. This study aimed to demonstrate the protective impact of ipragliflozin on lung damage induced in mice by Cecal Ligation and Puncture (CLP). The levels of lung tissue inflammatory & oxidative stress markers (IL-1β, IL-6, TNF-α, NF-KB & MDA) were significantly elevated in the sepsis in comparison to the sham. On other hand, mice treated with ipragliflozin had a significant reduction in the level of these mediators. Histological examination revealed significant lung tissue damage in mice undergo sepsis which significantly reduced after ipragliflozin treatment. Ipragliflozin shows promise in reducing pulmonary dysfunction in male mice with sepsis.

Keywords

• Endotoxemia
• Ipragliflozin
• NF-KB

Main Subjects

• Pharmaceutical sciences