Document Type : Original Research Article

Authors

• Asifa Bibi ¹
• Nabeela Tariq ²
• Hamida Ali ³
• Zil-e-Huma Butt ⁴
• Tasleem Kausar ⁵
• Maqsood Maryam ⁶

¹ SBK Women's University Brewery road Quetta

² Department of Zoology, Faculty of Life Sciences SBKW University Quetta, Balochistan (87300) Pakistan

³ SBK Women's University, Brewery road Quetta

⁴ SBK Women's University, Brewery Road Quetta

⁵ Sadiq College Women's University, Bahawalpur, Pakistan.

⁶ SBK Women's University, Brewery road Quetta

Abstract

KEL1 (Kell or K) is highly immunogenic with limited distribution while KEL2 (Cellano or k) antigen is more prevalent. The antigenic diversity in the Kell gene is a result of Single Nucleotide Polymorphisms (SNPs). Blood samples of 160 males and females from each ethnic group with no age restrictions were subjected to Tetra-ARMS PCR to genotype the SNP (C578T) on exon 6 of chromosome 7. Genotype and allele frequencies were estimated in correlation with gender, age, and ethnicity with p-value less than 0.05. In general, antigen KEL2 k was more prevalent than antigen KEL1 k.

Keywords

• Kell blood group
• ethnic population
• polymorphism

Main Subjects

• Biological sciences