Document Type : Review Article
10.22034/HBB.2021.03
Abstract
The COVID-19 virus is a subgroup of zoonotic viruses. The most terrible problem started when the number of infected patients with acute respiratory syndrome quickly spread around the world, which made it as a global pandemic. This novel virus could transmitted from person to person via infected droplet entering the respiratory system whether nasal or oral cavity. Close contact less than 6 feet, with infected individuals particularly in crowded environments has characterized the rapid spread of the infection. Clinical signs of the COVID-19 infection have mentioned the presence of some ocular findings such as conjunctival congestion, conjunctivitis and even corneal injury associated with the classical COVID-19 infection. In this review, we showed that different viruses could be and transmitted by tear fluid which encourage us to search regarding to this potential in COVID-19 virus.
Keywords
[1]. Aiello F., et al., Coronavirus disease 2019 (SARS-CoV-2) and colonization of ocular tissues and secretions: a systematic review. Eye (Lond), 2020. 34(7): 1206-11.
[2]. Eurosurveillance Editorial T. Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern. Euro Surveill, 2020. 25(5).
[3]. Report-22., W.H.O.N.C.-n.S. 2020.
[4]. Situation., W.H.O.N.C.C. 2020.
[5]. World Health Organization Coronavirus disease data, 2020.
[6]. Wu P et al. Characteristics of ocular findings of patients with Corona virus disease 2019 (COVID-19) in Hubei province, China. JAMA Ophthalmol, 2020.
[7]. Salata C et al. Coronaviruses: a paradigm of new emerging zoonotic diseases. Pathog Dis, 2019; 77(9).
[8]. Tekes G, Thiel HJ. Feline Coronaviruses: Pathogenesis of Feline infectious peritonitis. Adv Virus Res, 2016; 96: 193-218.
[9]. Nguyen van D et al. Characterization of canine coronavirus spread among domestic dogs in Vietnam. J Vet Med Sci, 2017. 79(2): 343-49.
[10].C.H.c.s., 27 2020.
[11]. Lu CW, et al. 2019-nCoV transmission through the ocular surface must not be ignored. Lancet, 2020; 395(10224): 39.
[12]. Holmes KV. SARS-associated coronavirus. N Engl J Med, 2003; 348(20): 1948-51.
[13]. Zhong NS, et al. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People Republic of China. Lancet, 2003; 362(9393): 1353-58.
[14]. Ksiazek TG, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Eng J Med, 2003; 348(20): 1953-66.
[15]. Zaki AM, et al. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med, 2012. 367(19): 1814-20.
[16]. Lauer SA, et al. The Incubation period of Corona virus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann Intern Med, 2020. 172(9): 577-82.
[17]. Guo YR, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak an update on the status. Mil Med Res, 2020. 7(1): 11.
[18]. Guan WJ, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med, 2020. 382(18): 1708-20.
[19]. Lechien JR, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol, 2020. 277(8): 2251-2261.
[20]. Seah I, Agrawal R. Can the Corona virus disease 2019 (COVID-19) affect the eyes? A review of Corona viruses and ocular implications in humans and animals. Ocul Immunol Inflamm, 2020. 28(3): 391-95.
[21].Pedersen SF, Ho YC. SARS-CoV-2: a storm is raging. J Clin Invest, 2020. 130(5): 2202-2205.
[22]. Xia J, et al., Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection. J Med Virol, 2020. 92(6): 589-94.
[23]. Seah IYJ, et al. Assessing viral shedding and infectivity of tears in corona virus disease 2019 (COVID-19) patients. Ophthalmology, 2020. 127(7): 977-79.
[24]. Colavita F, et al. SARS-CoV-2 isolation from ocular secretions of a patient with COVID-19 in Italy with prolonged viral RNA detection. Ann Intern Med, 2020. 173(3): 242-43.
[25]. Cheema M, et al. Keratoconjunctivitis as the initial medical presentation of the novel coronavirus disease 2019 (COVID-19). Can J Ophthalmol, 2020. 55(4): 125-29.
[26]. Yun H, et al. Laboratory data analysis of novel coronavirus (COVID-19) screening in 2510 patients. Clin Chim Acta, 2020. 507: 94-97.
[27]. Hu Y, et al. Positive detection of SARS-CoV-2 combined HSV1 and HHV6B virus nucleic acid in tear and conjunctival secretions of a non-conjunctivitis COVID-19 patient with obstruction of common lacrimal duct. Acta Ophthalmol, 2020.
[28]. Ozturker ZK. Conjunctivitis as sole symptom of COVID-19: A case report and review of literature. European Journal of Ophthalmology, 2020: 1-6.
[29]. Karimi S, et al. Detection of severe acute respiratory syndrome Coronavirus-2 in the tears of patients with Coronavirus disease 2019. Eye (Lond), 2020. 34(7): 1220-23.
[30]. Atum M, et al. Evaluation of conjunctival swab PCR results in patients with SARS-CoV-2 infection. Ocul Immunol Inflamm, 2020. 28(5): 745-48.
[31]. Loon SC, et al. The severe acute respiratory syndrome coronavirus in tears. Br J Ophthalmol, 2004. 88(7): 861-63.
[32]. Chan WM, et al. Tears and conjunctival scrapings for coronavirus in patients with SARS. Br J Ophthalmol, 2004. 88(7): 968-69.
[33]. Zhou Y, et al. Ophthalmologic evidence against the interpersonal transmission of 2019 novel coronavirus through conjunctiva. medRxiv, 2020.
[34]. Feucht HH, et al. Tear fluid of hepatitis C virus carriers could be infectious. J Clin Microbiol, 1995. 33(8): 2202-3.
[35]. Atas M, et al. The Investigation of HCV RNA in tear fluid and aqueous humor in patients with anti-HCV antibody positive who underwent cataract surgery. Ocul Immunol Inflamm, 2016. 24(3): 297-301.
[36]. Mendel I, et al. Detection and genotyping of the hepatitis C RNA in tear fluid from patients with chronic hepatitis C. J Med Virol, 1997. 51(3): 231-33.
[37]. Wenkel H, Krist D, Korn K. Detection of hepatitis C virus RNA in tear film of a patient with recurrent peripheral corneal ulcers. Klin Monbl Augenheilkd, 2001. 218(6): 459-62.
[38]. Emre S, et al. Transfusion-transmitted virus DNA in serum, tear and aqueous humour of patients undergoing cataract operation. Clin Exp Ophthalmol, 2007. 35(8): 759-62.
[39]. Fukuda M, et al. Presence of a large amount of herpes simplex virus genome in tear fluid of herpetic stromal keratitis and persistent epithelial defect patients. Semin Ophthalmol, 2008. 23(4): 217-20.
[40]. Huang FF, Wang ZJ , Zhang CR. Tear HSV-specific secretory IgA as a potential indicator for recurrent stromal herpes simplex keratitis: a preliminary study. Cornea, 2013. 32(7): 987-91.
[41]. Lee SY, et al. Comparative analysis of polymerase chain reaction assay for herpes simplex virus 1 detection in tear. Korean J Ophthalmol, 2013. 27(5): 316-21.
[42]. Satpathy G, et al. Evaluation of tear samples for Herpes Simplex Virus 1 (HSV) detection in suspected cases of viral keratitis using PCR assay and conventional laboratory diagnostic tools. Br J Ophthalmol, 2011. 95(3): 415-18.
[43]. Ramchandani M, et al. Herpes simplex virus type 1 shedding in tears and nasal and oral mucosa of healthy adults. Sex Transm Dis, 2016. 43(12): 756-60.
[44]. Reyes-Goddard JM, Barr H, Stone N. Surface enhanced Raman scattering of herpes simplex virus in tear film. Photodiagnosis Photodyn Ther, 2008. 5(1): 42-49.
[45]. Abiko Y, Ikeda M, Hondo R. Secretion and dynamics of herpes simplex virus in tears and saliva of patients with Bell's palsy. Otol Neurotol, 2002. 23(5): 779-83.
[46]. Shinoda K, et al. Detection of measles virus genomic RNA in tear samples from a patient with measles keratitis. Cornea, 2002. 21(6): 610-12.
[47]. Hiroshige K, Ikeda M, Hondo R. Detection of varicella-zoster virus DNA in tear fluid and saliva of patients with Ramsay Hunt syndrome. Nihon Jibiinkoka Gakkai Kaiho, 2000. 103(8): 928-36.
[48]. Pitkaranta A, et al. Detection of human herpesvirus 6 and varicella-zoster virus in tear fluid of patientswith Bell's palsy by PCR. J Clin Microbiol, 2000. 38(7): 2753-55.
[49]. Rozanova EB, et al. Cytomegalovirus antibodies in tear fluid of patients with retinitis. Arch Virol, 2006. 151(12): 2407-17.
[50]. Willoughby CE, et al. Epstein-Barr virus (types 1 and 2) in the tear film in Sjogren's syndrome and HIV infection. J Med Virol, 2002. 68(3): 378-83.
[51]. Ganapathy K, Cargill PW, Jones RC. A comparison of methods of inducing lachrymation and tear collection in chickens for detection of virus-specific immuoglobulins after infection with infectious bronchitis virus. Avian Pathol, 2005. 34(3): 248-51.
[52]. Tan JJL, et al. Persistence of Zika virus in conjunctival fluid of convalescence patients. Sci Rep, 2017. 7(1): 11194.
[53]. Miner JJ, et al. Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears. Cell Rep, 2016. 16(12): 3208-18.
[54]. Han Y, et al. Detection of HIV-1 viruses in tears of patients even under long-term HAART. AIDS, 2011. 25(15): 1925-27.
[55]. Di Y, et al. Fundus manifestations and HIV viral loads of AIDS patients before and after HAART. Int J Ophthalmol, 2019. 12(9): 1438-43.
[56]. Balne PK, et al. Dataset of longitudinal analysis of tear cytokine levels, CD4, CD8 counts and HIV viral load in dry eye patients with HIV infection. Data Brief, 2017. 11: 152-54.
[57]. Kaye SB, et al. Evidence for persistence of adenovirus in the tear film a decade following conjunctivitis. J Med Virol, 2005. 77(2): 227-31.
[58]. Fox GM, et al. Detection of herpesvirus DNA in vitreous and aqueous specimens by the polymerase chain reaction. Arch Ophthalmol, 1991. 109(2): 266-71.
[59]. Crouse CA, et al. Detection of herpes viral genomes in normal and diseased corneal epithelium. Curr Eye Res, 1990. 9(6): 569-81.
[60]. Koizumi N, et al. Detection of herpes simplex virus DNA in atypical epithelial keratitis using polymerase chain reaction. Br J Ophthalmol, 1999. 83(8): 957-60.
[61]. Liang L, Wu P. There may be virus in conjunctival secretion of patients with COVID-19. Acta Ophthalmol, 2020. 98(3): 223.
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